The quest for a truly universal influenza vaccine
YH Jang, BL Seong - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
There is an unmet public health need for a universal influenza vaccine (UIV) to provide
broad and durable protection from influenza virus infections. The identification of broadly …
broad and durable protection from influenza virus infections. The identification of broadly …
Animal models for influenza research: strengths and weaknesses
Influenza remains one of the most significant public health threats due to its ability to cause
high morbidity and mortality worldwide. Although understanding of influenza viruses has …
high morbidity and mortality worldwide. Although understanding of influenza viruses has …
Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses
Messenger RNA (mRNA) vaccines represent a new, effective vaccine platform with high
capacity for rapid development. Generation of a universal influenza virus vaccine with the …
capacity for rapid development. Generation of a universal influenza virus vaccine with the …
Influenza A virus is transmissible via aerosolized fomites
S Asadi, N Gaaloul ben Hnia, RS Barre… - Nature …, 2020 - nature.com
Influenza viruses are presumed, but not conclusively known, to spread among humans by
several possible routes. We provide evidence of a mode of transmission seldom considered …
several possible routes. We provide evidence of a mode of transmission seldom considered …
Human anti-N1 monoclonal antibodies elicited by pandemic H1N1 virus infection broadly inhibit HxN1 viruses in vitro and in vivo
Neuraminidase (NA) is one of the two influenza virus surface glycoproteins, and antibodies
that target it are an independent correlate of protection. However, our current understanding …
that target it are an independent correlate of protection. However, our current understanding …
Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity
RK Virk, J Jayakumar, IH Mendenhall… - Proceedings of the …, 2020 - National Acad Sciences
Influenza B viruses have circulated in humans for over 80 y, causing a significant disease
burden. Two antigenically distinct lineages (“B/Victoria/2/87-like” and “B/Yamagata/16/88 …
burden. Two antigenically distinct lineages (“B/Victoria/2/87-like” and “B/Yamagata/16/88 …
[HTML][HTML] Human antibodies targeting influenza B virus neuraminidase active site are broadly protective
Influenza B virus (IBV) infections can cause severe disease in children and the elderly.
Commonly used antivirals have lower clinical effectiveness against IBV compared to …
Commonly used antivirals have lower clinical effectiveness against IBV compared to …
A novel recombinant influenza virus neuraminidase vaccine candidate stabilized by a measles virus phosphoprotein tetramerization domain provides robust …
S Strohmeier, F Amanat, X Zhu, M McMahon… - MBio, 2021 - Am Soc Microbiol
Current seasonal influenza virus vaccines do not induce robust immune responses to
neuraminidase. Several factors, including immunodominance of hemagglutinin over …
neuraminidase. Several factors, including immunodominance of hemagglutinin over …
Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle
Annual influenza vaccination is recommended to update the variable hemagglutinin
antigens. Here, we first designed a virus-like particle (VLP) displaying consensus multi …
antigens. Here, we first designed a virus-like particle (VLP) displaying consensus multi …
Sex differences in influenza: the challenge study experience
LT Giurgea, A Cervantes-Medina… - The Journal of …, 2022 - academic.oup.com
Background Preclinical animal studies and retrospective human studies suggest that adult
females have worse outcomes from influenza than males. Prospective studies in humans …
females have worse outcomes from influenza than males. Prospective studies in humans …