Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …

Abstracts Bone mainly functions as a supportive framework for the whole body and is the
major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing …

The multiple endocrine functions of bone other than those related to mineral metabolism,
such as regulation of insulin sensitivity, glucose homeostasis, and energy metabolism, have …

Increased circulating sclerostin and accumulation of advanced glycation end‐products
(AGEs) are two potential mechanisms underlying low bone turnover and increased fracture …

Objective To assess whether eldecalcitol, an active vitamin D analogue 2, can reduce the
development of type 2 diabetes among adults with impaired glucose tolerance. Design …

Individuals with type 2 diabetes mellitus (T2DM) have an increased risk of bone fragility
fractures compared to nondiabetic subjects. This increased fracture risk may occur despite …

Bone fragility has been recognized as a complication of diabetes, both type 1 diabetes (T1D)
and type 2 diabetes (T2D), whereas the relationship between prediabetes and fracture risk …

Context Adults with type 2 diabetes (T2D) have higher fracture risk compared with
nondiabetics, despite having higher bone mineral density (BMD). Insulin resistance (IR) has …

Objective To reveal the relationship between Body Mass Index (BMI), type 2 diabetes, and
bone mineral density (BMD) using a mendelian randomization (MR) approach. Methods …

Bone regeneration following trauma, tumor resection, infection, or congenital disease is
challenging. Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia …