Microglia, the immunocompetent cells of the central nervous system (CNS), act as
neuropathology sensors and are neuroprotective under physiological conditions. Microglia …

Alzheimer's disease (AD) is one of the most common types of age-related dementia
worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary …

Microglia are the main effectors in the inflammatory process of the central nervous system.
As the first line of defense, microglia play an important role in the inflammatory reaction …

Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Glaucoma is a complex neurodegenerative disease with many clinical subtypes. Some of its
rare forms include pigmentary glaucoma, uveitic glaucoma and congenital glaucoma. While …

Neuropathic pain, a maladaptive and chronic condition that can develop after a lesion or
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …

Inflammation is a crucial and complex process that reestablishes the physiological state after
a noxious stimulus. In pathological conditions the inflammatory state may persist, leading to …

Microglia represent the primary resident immune cells of the central nervous system (CNS)
and modulate local immune responses. Depending on their physiological functions …

Background Parkinson's disease (PD) is the most prevalent neurodegenerative disorder that
is characterised by selective loss of midbrain dopaminergic (DA) neurons. Chronic …

abstract Neurodegenerative diseases (NDs) are characterized by the progressive loss of
structure and function of neurons most common in elderly population, mainly including …