An overview of coumarin as a versatile and readily accessible scaffold with broad-ranging biological activities
F Annunziata, C Pinna, S Dallavalle… - International Journal of …, 2020 - mdpi.com
Privileged structures have been widely used as an effective template for the research and
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …
Synthetic and natural coumarins as potent anticonvulsant agents: A review with structure–activity relationship
RS Keri, S Budagumpi… - Journal of Clinical …, 2022 - Wiley Online Library
What is known and objective The main objective of this review is to highlight the most
relevant studies since 1990 (to date) in the area of medicinal chemistry aspects to provide a …
relevant studies since 1990 (to date) in the area of medicinal chemistry aspects to provide a …
Recurrent π–π stacking motifs in three new 4, 5-dihydropyrazolyl–thiazole–coumarin hybrids: X-ray characterization, Hirshfeld surface analysis and DFT calculations
The synthesis and X-ray characterization of three new 4, 5-dihydropyrazolylthiazole–
coumarin hybrids (1–3) are reported herein, namely 3-(2-(3, 5-bis (4-chlorophenyl)-4, 5 …
coumarin hybrids (1–3) are reported herein, namely 3-(2-(3, 5-bis (4-chlorophenyl)-4, 5 …
Overview on developed synthesis procedures of coumarin heterocycles
MM Zeydi, SJ Kalantarian, Z Kazeminejad - Journal of the Iranian …, 2020 - Springer
Considering highly valuable biological and pharmaceutical properties of coumarins, the
synthesis of these heterocycles has been considered for many organic and pharmaceutical …
synthesis of these heterocycles has been considered for many organic and pharmaceutical …
In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1, 2, 4-oxadiazole analogues against Mycobacterium …
The alarming increase in multi-and extensively drug-resistant (MDR and XDR) strains of
Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for …
Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for …
Experimental models for the discovery of novel anticonvulsant drugs: focus on pentylenetetrazole-induced seizures and associated memory deficits
Epilepsy is a chronic neurological disorder characterized by irregular, excessive neuronal
excitability, and recurrent seizures that affect millions of patients worldwide. Currently …
excitability, and recurrent seizures that affect millions of patients worldwide. Currently …
Synthesis and antimicrobial activity of new series of thiazoles, pyridines and pyrazoles based on coumarin moiety
MT Sayed, SA Elsharabasy, A Abdel-Aziem - Scientific Reports, 2023 - nature.com
Microbial infections are currently a widespread disease in hospitals and community health
centres and are a major cause of death worldwide. In pursuit of searching new antimicrobial …
centres and are a major cause of death worldwide. In pursuit of searching new antimicrobial …
In silico molecular modeling, neuro-behavioral profile, and toxicity assessment of the essential oil of Ferula gummosa Boiss. As an anti-seizure agent
Abstract Ethnopharmacological relevance Ferula gummosa Boiss., known in Persian as
“Baridje,” belongs to the Apiaceae family. All parts of this plant, especially the root, contain …
“Baridje,” belongs to the Apiaceae family. All parts of this plant, especially the root, contain …
Synthesis and X‐ray characterization of 4, 5‐dihydropyrazolyl‐thiazoles bearing a coumarin moiety: on the importance of antiparallel π‐stacking
The synthetic protocol and solid state characterization of two new coumarin‐
pyrazolylthiazole hybrids (1‐2) are detailed in this manuscript. Synthesized compounds …
pyrazolylthiazole hybrids (1‐2) are detailed in this manuscript. Synthesized compounds …
Overview of chemistry and therapeutic potential of non-nitrogen heterocyclics as anticonvulsant agents
Epilepsy is a chronic neurological disorder, characterized by the predisposition of
unprovoked seizures affecting the neurobiological, psychological, cognitive, economic, and …
unprovoked seizures affecting the neurobiological, psychological, cognitive, economic, and …