[HTML][HTML] Estrogen: the necessary evil for human health, and ways to tame it

S Patel, A Homaei, AB Raju, BR Meher - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Estrogen is a pivotal enzyme for survival and health in both genders, though their quantum,
tropism, tissue-specific distribution, and receptor affinity varies with different phases of life …

Disruption of aromatase homeostasis as the cause of a multiplicity of ailments: A comprehensive review

S Patel - The Journal of steroid biochemistry and molecular …, 2017 - Elsevier
Human health is beset with a legion of ailments, which is exacerbated by lifestyle errors. Out
of the numerous enzymes in human body, aromatase, a cytochrome P450 enzyme is …

Oxytocin and steroid actions

GF Jirikowski, SD Ochs, JD Caldwell - Behavioral Pharmacology of …, 2018 - Springer
Biosynthesis and secretion of the hypothalamic nonapeptide oxytocin largely depends on
steroid hormones. Estradiol, corticosterone, and vitamin D seem to be the most prominent …

Aromatase inhibitors as a therapeutic strategy for male prolactinoma resistant to dopamine agonists: a retrospective cohort study and literature review

D Zúñiga, MAM Stumpf, ALS Monteiro… - Journal of …, 2024 - Springer
Purpose To assess the effect of letrozole, an aromatase inhibitor (AI), in patients with
resistant prolactinoma that presented an increase in serum prolactin (PRL) levels during …

TRPV1 may increase the effectiveness of estrogen therapy on neuroprotection and neuroregeneration

R Ramírez-Barrantes, I Marchant… - Neural Regeneration …, 2016 - journals.lww.com
Aging induces physical deterioration, loss of the blood brain barrier, neuronal loss-induced
mental and neurodegenerative diseases. Hypotalamus-hypophysis-gonad axis aging …

Aromatized estrogens amplify nocturnal growth hormone secretion in testosterone-replaced older hypogonadal men

F Roelfsema, RJ Yang, PY Takahashi… - The Journal of …, 2018 - academic.oup.com
Abstract Context Testosterone (T) increases GH secretion in older men with a relative lack of
T, in hypogonadal men of all ages, and in patients undergoing sex reassignment. The role of …

From biosynthesis to therapeutics: A comprehensive review on varied functions of estrogen and selective estrogen receptor modulators

A Sant, I Ahmad, S Bhatia, A Gupta - Journal of Molecular Structure, 2025 - Elsevier
Estrogens are endogenous hormones vital in many physiological functions in both sexes. An
imbalance in the cumulative estrogen concentration creates many health problems …

Pituitary hyperplasia, hormonal changes and prolactinoma development in males exposed to estrogens—an insight from translational studies

B Šošić-Jurjević, V Ajdžanović, D Miljić… - International Journal of …, 2020 - mdpi.com
Estrogen signaling plays an important role in pituitary development and function. In sensitive
rat or mice strains of both sexes, estrogen treatments promote lactotropic cell proliferation …

Relation among aromatase P450 and tumoral growth in human prolactinomas

MJ García-Barrado, EJ Blanco… - International Journal of …, 2017 - mdpi.com
The pituitary gland is part of hypothalamic-pituitary–gonadal axis, which controls
development, reproduction, and aging in humans and animals. In addition, the pituitary …

Effects of melatonin and gonadal androgens on cell proliferation in the pituitary of viscachas (Lagostomus maximus maximus)

GJ Rosales, FI Busolini, FH Mohamed… - Cell …, 2016 - Wiley Online Library
Objectives Melatonin and androgens are involved in the regulation of cell proliferation.
However, effects of these hormones on pituitary pars distalis (PD) of male viscachas is not …