Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Mn (III) porphyrins as potential MRI contrast agents for diagnosis and MRI-guided therapy

CFGC Geraldes, MMCA Castro, JA Peters - Coordination Chemistry …, 2021 - Elsevier
Mn (III) porphyrins have great potential as Gd-free MRI contrast agents because both the
cation and the ligand have interesting properties. The redox properties of the Mn (III)-ion can …

Iron (III)‐quercetin complex: Synthesis, physicochemical characterization, and MRI cell tracking toward potential applications in regenerative medicine

P Papan, J Kantapan, P Sangthong… - Contrast Media & …, 2020 - Wiley Online Library
In cell therapy, contrast agents T1 and T2 are both needed for the labeling and tracking of
transplanted stem cells over extended periods of time through magnetic resonance imaging …

Research progress on manganese complexes as contrast agents for magnetic resonance imaging

F Wan, L Wu, X Chen, Y Zhang, L Jiang - Polyhedron, 2023 - Elsevier
Gadolinium (III)-based contrast agents (GBCAs) play a dominant role in contrast enhanced
magnetic resonance imaging (MRI) and are used to improve the accuracy of diagnoses. In …

A primer on in vivo cell tracking using MRI

HLM Cheng - Frontiers in Medicine, 2023 - frontiersin.org
Cell tracking by in vivo magnetic resonance imaging (MRI) offers a collection of multiple
advantages over other imaging modalities, including high spatial resolution, unlimited depth …

A manganese porphyrin-based T1 contrast agent for cellular MR imaging of human embryonic stem cells

A Venter, DA Szulc, S Loai, T Ganesh, IE Haedicke… - Scientific Reports, 2018 - nature.com
MRI for non-invasive cell tracking is recognized for enabling pre-clinical research on stem
cell therapy. Yet, adoption of cellular imaging in stem cell research has been restricted to …

Manganese-porphyrin-enhanced MRI for the detection of cancer cells: A quantitative in vitro investigation with multiple clinical subtypes of breast cancer

M Alhamami, W Cheng, Y Lyu, C Allen, X Zhang… - PLoS …, 2018 - journals.plos.org
Magnetic resonance imaging (MRI) contrast agents (CAs) are chemical compounds that can
enhance image contrast on T1-or T2-weighted MR image. We have previously …

Noninvasive strategies of cell-tracking in vivo

Y Han, Y Li, WE Wu, Z Liu - TrAC Trends in Analytical Chemistry, 2024 - Elsevier
In recent years, cell-based therapy, such as adoptive immunotherapy and stem cell
restorative therapy, was followed with interest. However, restricted understanding of the …

An Efficient T1 Contrast Agent for Labeling and Tracking Human Embryonic Stem Cells on MRI

IE Haedicke, S Loai, HLM Cheng - Contrast media & molecular …, 2019 - Wiley Online Library
Noninvasive cell tracking in vivo has the potential to advance stem cell‐based therapies into
the clinic. Magnetic resonance imaging (MRI) provides an excellent image‐guidance …

Efficient one-step amide formation using amino porphyrins

KDW Vollett, HLM Cheng - Organic & Biomolecular Chemistry, 2024 - pubs.rsc.org
Amide bonds are one of the most prevalent phenomena in nature and are utilized frequently
in drug and material design. However, forming amide bonds is not always efficient or high …