Oxidants are produced as a by-product of aerobic metabolism, and organisms ranging from
prokaryotes to mammals have evolved with an elaborate and redundant complement of …

This review will focus on the transport and intracellular formation of S-nitrosothiols in cell
culture models. The major points made in this article are:(1) S-Nitrosothiols are actively …

Glutathione represents the major low molecular weight antioxidant redox recycling thiol in
mammalian cells and plays a central role in the cellular defence against oxidative damage …

Nitric oxide (NO) possesses antiinflammatory effects, which may be exerted via its ability to
inhibit the transcription factor, NF-κB. A commonly proposed mode of action for inhibition of …

The role of nitric oxide in several signalling routes has been clearly established. In recent
years increasing attention has been paid to its ability to produce covalent protein post …

The reactive cysteines in H-ras are subject to oxidative modifications that potentially alter the
cellular function of this protein. In this study, purified H-ras was modified by thiol oxidants …

S-nitrosothiols have been suggested to play an important role in nitric oxide (NO)-mediated
biological events. However, the mechanisms by which an S-nitrosothiol (or the S-nitroso …

Thiols affect a variety of cell functions, an effect known as redox regulation. We show here
that treatment (1–2 h) of cells with 0.1–5 mM N-acetyl-l-cysteine (NAC) increases surface …

We have analyzed the effects of the endogenous redoxactive agents S-nitrosoglutathione
and glutathione disulfide, and the NO donor NOR-3, on calcium release kinetics mediated …

Previous studies have shown that a Ca 2+-dependent nitric-oxide synthase (NOS) is
activated as part of a cellular response to low doses of ionizing radiation. Genetic and …