The modern lifestyle has a negative impact on health. It is usually accompanied by
increased stress levels and lower physical activity, which interferes with body homeostasis …

Physical inactivity represents a heavy burden for modern societies and is spreading
worldwide, it is a recognised pandemic and is the fourth cause of global mortality. Not …

While impairments in peripheral tissue insulin signalling have a well-characterized role in
the development of insulin resistance and type 2 diabetes (T2D), the specific mechanisms …

Abstract Type 2 diabetes (T2DM) is a well known risk factor for Alzheimer's disease.
Mitochondria are the center of intracellular energy metabolism and the main source of …

The increasing prevalence of age-related diseases and resulting healthcare insecurity and
emotional burden require novel treatment approaches. Several promising strategies seek to …

Toll-like receptor 4 (TLR4) is a proposed mediator of ceramide accumulation, muscle
atrophy, and insulin resistance in skeletal muscle. It is currently unknown whether …

Historically, lipid panels have been used to predict cardiovascular risk. However, individuals
with well-controlled lipid levels continue to have cardiac events. Recent advances in …

Background Recent findings indicate that ghrelin, particularly the unacylated form (UnAG),
acutely stimulates skeletal muscle fatty acid oxidation (FAO) and can preserve insulin …

Insufficient physical activity is associated with increased relative risk of cardiometabolic
disease and is an independent risk factor for mortality. Experimentally reducing physical …

Accumulating evidence in several model organisms indicates that reduced sphingolipid
biosynthesis promotes longevity, although underlying mechanisms remain unclear. In yeast …