Revisiting airflow and aerosol transport phenomena in the deep lungs with microfluidics

J Sznitman - Chemical Reviews, 2021 - ACS Publications
The dynamics of respiratory airflows and the associated transport mechanisms of inhaled
aerosols characteristic of the deep regions of the lungs are of broad interest in assessing …

Multiscale Modeling of Respiratory Transport Phenomena and Intersubject Variability

SC Kassinos, J Sznitman - Annual Review of Fluid Mechanics, 2024 - annualreviews.org
Our understanding of respiratory flow phenomena has been consolidated over decades with
the exploration of in vitro and in silico canonical models that underscore the multiscale fluid …

Analysis of flow field and turbulence predictions in a lung model applying RANS and implications for particle deposition

M Sommerfeld, OL Sgrott Jr, MA Taborda… - European Journal of …, 2021 - Elsevier
Airflow and aerosol deposition in the human airways are important aspects for applications
such as pulmonary drug delivery and human exposure to aerosol pollutants. Numerical …

[HTML][HTML] A critical analysis of the CFD-DEM simulation of pharmaceutical aerosols deposition in extra-thoracic airways

GH Spasov, R Rossi, A Vanossi, C Cottini… - International Journal of …, 2022 - Elsevier
Recent advances in the characterization of the human respiratory system and in multi-phase
flow dynamics in complex geometries have led numerical simulations to play an expanding …

The effect of oral and nasal breathing on the deposition of inhaled particles in upper and tracheobronchial airways

F Lizal, J Elcner, J Jedelsky, M Maly, M Jicha… - Journal of aerosol …, 2020 - Elsevier
The inhalation route has a substantial influence on the fate of inhaled particles. An outbreak
of infectious diseases such as COVID-19, influenza or tuberculosis depends on the site of …

In vitro–in silico correlation of three-dimensional turbulent flows in an idealized mouth-throat model

E Nof, S Bhardwaj, P Koullapis, R Bessler… - PLOS Computational …, 2023 - journals.plos.org
There exists an ongoing need to improve the validity and accuracy of computational fluid
dynamics (CFD) simulations of turbulent airflows in the extra-thoracic and upper airways …

[HTML][HTML] A critical analysis of the CFD-DEM simulation of pharmaceutical aerosols deposition in upper intra-thoracic airways: Considerations on air flow

GH Spasov, R Rossi, A Vanossi, C Cottini… - Computers in Biology …, 2024 - Elsevier
A well-corroborated numerical methodology ensuring reproducibility in the modeling of
pharmaceutical aerosols deposition in the respiratory system via CFD-DEM simulations …

Multiscale in silico lung modeling strategies for aerosol inhalation therapy and drug delivery

P Koullapis, B Ollson, SC Kassinos… - Current opinion in …, 2019 - Elsevier
Inhalation therapy is a hallmark of modern respiratory medicine. Over recent years,
computational fluid-particle dynamics (CFPD) simulations of respiratory airflows and aerosol …

[HTML][HTML] Part2Track: A MATLAB package for double frame and time resolved particle tracking velocimetry

T Janke, R Schwarze, K Bauer - SoftwareX, 2020 - Elsevier
Within this paper we present Part2Track, a MATLAB software package for the evaluation of
2D Particle Tracking Velocimetry (PTV) measurements. Part2Track is not only capable of …

Dry powder inhaler deposition in the larynx and the risk of steroid inhaler laryngitis: A computational fluid dynamics study

S Dey, JM Bock, GJM Garcia - Journal of Aerosol Science, 2025 - Elsevier
Abstract Dry Powder Inhalers (DPIs) are a mainstay in the treatment of obstructive
respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD) …