Emerging molecular markers towards potential diagnostic panels for lupus

G Tan, B Baby, Y Zhou, T Wu - Frontiers in Immunology, 2022 - frontiersin.org
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease which can affect
various tissues and organs, posing significant challenges for clinical diagnosis and …

Role of miR-155 in inflammatory autoimmune diseases: a comprehensive review

WD Xu, SY Feng, AF Huang - Inflammation Research, 2022 - Springer
Purpose MiR-155 is a member of the microRNAs (miRNAs) family and regulates gene
expression post-transcriptionally by binding to the 3'UTR of target mRNA. MiR-155 has a …

MicroRNAs in lupus nephritis–role in disease pathogenesis and clinical applications

BYF So, DYH Yap, TM Chan - International journal of molecular sciences, 2021 - mdpi.com
MicroRNAs (miRs) are non-coding small RNAs that act as epigenetic modulators to regulate
the protein levels of target mRNAs without modifying the genetic sequences. The role of …

A comprehensive review on miR-146a molecular mechanisms in a wide spectrum of immune and non-immune inflammatory diseases

SS Mortazavi-Jahromi, M Aslani, A Mirshafiey - Immunology Letters, 2020 - Elsevier
MicroRNAs (miRNAs) are single-strand endogenous and non-coding RNA molecules with a
length of about 22 nucleotides, which regulate genes expression, through modulating the …

Lupus nephritis biomarkers: a critical review

FK Alduraibi, GC Tsokos - International Journal of Molecular Sciences, 2024 - mdpi.com
Lupus nephritis (LN), a major complication in individuals diagnosed with systemic lupus
erythematosus, substantially increases morbidity and mortality. Despite marked …

Crosstalk between miR-146a and pro-inflammatory cytokines in patients with systemic lupus erythematosus

BA El-Akhras, RM Talaat, SA El-Masry… - International …, 2023 - journals.sagepub.com
microRNA-146a (miR-146a) plays an essential role in immune anomalies and organ injury
of systemic lupus erythematosus (SLE) by regulating the disease's inflammation and …

Circulatory microRNAs and proinflammatory cytokines as predictors of lupus nephritis

DS ElFeky, NM Omar, OG Shaker… - Frontiers in …, 2024 - frontiersin.org
Introduction Lupus nephritis (LN) is one of the most prevalent severe organ manifestations of
systemic lupus erythematosus (SLE), impacting 70% of SLE patients. MicroRNAs (miRNAs) …

Transcriptomic and epigenetic alterations in dendritic cells correspond with chronic kidney disease in lupus nephritis

A Wardowska, M Komorniczak… - Frontiers in …, 2019 - frontiersin.org
Systemic lupus erythematosus (SLE) is a serious autoimmune disease with variety of organ
manifestations. The most dreadful one, affecting the majority of SLE patients, is kidney …

Cross-talk between mitochondrial dysfunction-provoked oxidative stress and aberrant noncoding RNA expression in the pathogenesis and pathophysiology of SLE

CY Tsai, SC Hsieh, CS Lu, TH Wu, HT Liao… - International Journal of …, 2019 - mdpi.com
Systemic lupus erythematosus (SLE) is a prototype of systemic autoimmune disease
involving almost every organ. Polygenic predisposition and complicated epigenetic …

Molecular and cellular bases of immunosenescence, inflammation, and cardiovascular complications mimicking “inflammaging” in patients with systemic lupus …

CY Tsai, CY Shen, HT Liao, KJ Li, HT Lee… - International Journal of …, 2019 - mdpi.com
Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disease,
characterized by the presence of diverse autoantibodies and chronic inflammation. There …