Androgen deficiency and phosphodiesterase type 5 expression changes in aging male: therapeutic implications

A Aversa, Y Duca, RA Condorelli… - Frontiers in …, 2019 - frontiersin.org
The age-related decline of serum T occurs in~ 20–30% of adult men and it is today defined
as late-onset hypogonadism (LOH). In the elderly, such decline becomes more prevalent (up …

Effects of nitric oxide on steroidogenesis and apoptosis in goat luteinized granulosa cells

YX Guo, GM Zhang, XL Yao, R Tong, CY Cheng… - Theriogenology, 2019 - Elsevier
The aim of this study was to investigate effects of nitric oxide (NO) on steroidogenesis and
apoptosis in goat luteinized granulosa cells (LGCs). We cultured goat LGCs from healthy …

Nitric oxide-induced lipophagic defects contribute to testosterone deficiency in rats with spinal cord injury

Y Zhuang, W Liu, F Chen, M Xie, H Zhang… - Frontiers in …, 2024 - frontiersin.org
Introduction Males with acute spinal cord injury (SCI) frequently exhibit testosterone
deficiency and reproductive dysfunction. While such incidence rates are high in chronic …

Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice

J Li, Y Jiang, W Xue, L Liu, H Yu, X Zhang… - Regenerative …, 2023 - Taylor & Francis
Aim: This study investigated the effect of allografting umbilical cord blood mononuclear cells
(UCBMCs) into the scrotum on sexual function in male elderly mice. Methods: UCBMCs …

Effect of heat stress and Hsp90 inhibition on T-type calcium currents and voltage-dependent potassium currents in leydig cells

BM Tenorio, RP da Silva, FCAM Tenorio… - Journal of thermal …, 2019 - Elsevier
Heat can trigger testicular damage and impair fertility. Leydig cells produce testosterone in
response to stimulation by luteinizing hormone (LH), which induces Ca 2+ entry and K+ …

Panax Notoginseng Saponins Attenuates the ATP Induced Increases of Intracellular Ca2+ in Sertoli cells: Involvement of PLC signaling pathway

F Zhang, Z Xiong - IOP Conference Series: Earth and …, 2019 - iopscience.iop.org
Panax notoginseng saponin (PNS) is a traditional Chinese medicine. Recent studies
showed that Panax ginseng, a member of the same PNS family, improves sperm motility in …