The schizophrenia syndrome, circa 2024: What we know and how that informs its nature
R Tandon, H Nasrallah, S Akbarian… - Schizophrenia …, 2024 - Elsevier
With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …
becomes necessary to periodically revisit exactly what we know. Along with a need to review …
Genomic findings in schizophrenia and their implications
There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy
G Hindley, AA Shadrin, D van der Meer… - Nature human …, 2023 - nature.com
Personality and cognitive function are heritable mental traits whose genetic foundations may
be distributed across interconnected brain functions. Previous studies have typically treated …
be distributed across interconnected brain functions. Previous studies have typically treated …
Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis
Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and
gastrointestinal disorders. A recent genome-wide association study (GWAS) identified …
gastrointestinal disorders. A recent genome-wide association study (GWAS) identified …
Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders
Psychiatric disorders and common epilepsies are heritable disorders with a high comorbidity
and overlapping symptoms. However, the causative mechanisms underlying this …
and overlapping symptoms. However, the causative mechanisms underlying this …
Investigating the shared genetic architecture between depression and subcortical volumes
M Liu, L Wang, Y Zhang, H Dong, C Wang… - Nature …, 2024 - nature.com
Depression, a widespread and highly heritable mental health condition, profoundly affects
millions of individuals worldwide. Neuroimaging studies have consistently revealed …
millions of individuals worldwide. Neuroimaging studies have consistently revealed …
Recommendations for reducing the risk of cannabis use-related adverse psychosis outcomes: a public mental health-oriented evidence review
Objective: Cannabis use is increasingly normalized; psychosis is a major adverse health
outcome. We reviewed evidence on cannabis use-related risk factors for psychosis …
outcome. We reviewed evidence on cannabis use-related risk factors for psychosis …
The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study
Background The relationship between psychotic disorders and cannabis use is heavily
debated. Shared underlying genetic risk is one potential explanation. We investigated the …
debated. Shared underlying genetic risk is one potential explanation. We investigated the …
Psychiatric disorders and brain white matter exhibit genetic overlap implicating developmental and neural cell biology
Improved understanding of the shared genetic architecture between psychiatric disorders
and brain white matter may provide mechanistic insights for observed phenotypic …
and brain white matter may provide mechanistic insights for observed phenotypic …