Abstract PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …

Chemoresistance of cancer cells is a major problem in treating cancer. Knowledge of how
cancer cells may die or resist cancer drugs is critical to providing certain strategies to …

Ovarian high-grade serous carcinoma (HGSC) is typically diagnosed at an advanced stage,
with multiple genetically heterogeneous clones existing in the tumors long before …

Mammary tumors in dogs hold great potential as naturally occurring breast cancer models in
translational oncology, as they share the same environmental risk factors, key histological …

Genetic and epigenetic alterations have been under concentrated investigations for many
years in order to unearth the molecules regulating human cancer pathogenesis. However …

Cancer is a systemic manifestation of aberrant cell cycle activity and dysregulated cell
growth. Genetic mutations can determine tumor onset by either augmenting cell division …

PIK3CA is the second most mutated gene in cancer leading to aberrant PI3K/AKT/mTOR
signaling and increased translation, proliferation, and survival. Some 4%–25% of gastric …

Abstract The phosphoinositide 3-kinase (PI3K) signaling pathway is well-known for its
important role in cancer growth, proliferation and migration. The activation of PI3K pathway …

Protein kinases are key regulators of cellular signaling and play a critical role in
oncogenesis. Inhibitors of protein kinases are pursued by both industry and academia as a …

Abstract The PI3K-Akt-mTOR (PAM) pathway is implicated in tumor progression in many
tumor types, including metastatic gastric cancer (GC). The initial promise of PAM inhibitors …