Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …

Multiple myeloma (MM) is an incurable blood cancer that primarily affects older adults.
Several frailty tools have been developed to address the heterogeneity of aging in this …

Older adults represent a vulnerable population with elevated risk for numerous morbidities.
To explore the association of the microbiome with aging and age-related susceptibilities …

William Osler, generally considered the Father of Modern Medicine, commented that
variability among individuals represented the main barrier to medical practice transitioning …

To define metrics of phenotypic aging, it is essential to identify biological and environmental
factors that influence the pace of aging. Previous attempts to develop aging metrics were …

Aging is a complex biological process with multifactorial nature underlined by genetic,
environmental, and social factors. In the present paper, we review several mechanisms of …

Background There are considerable gaps between the need for assistive technologies and
the actual adoption of these technologies among older adults, although older adults are …

Abstract Purpose of Review Deep tissue HIV reservoirs, especially within the central
nervous system (CNS), are understudied due to the challenges of sampling brain, spinal …

Older adults share a growing burden of cancer morbidity and mortality. This is present
across the spectrum of oncologic diagnoses and is particularly true with colorectal cancer …

While chronological age is the single biggest risk factor for cancer, it is less clear whether
frailty, an age-related state of physiological decline, may also predict cancer incidence. We …