Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

The rapid rise of obesity during the past decades has coincided with a profound shift of our
living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical …

For any given level of overall adiposity, individuals vary considerably in fat distribution. The
inherited basis of fat distribution in the general population is not fully understood. Here, we …

Many of the established positive health benefits of exercise have been documented by
historical discoveries in the field of exercise physiology. These investigations often assess …

Body mass index (BMI), a proxy measure for obesity, is determined by both environmental
(including ethnicity, age, and sex) and genetic factors, with> 400 BMI-associated loci …

In recent years pleiotropy, the phenomenon of one genetic locus influencing several traits,
has become a widely researched field in human genetics. With the increasing availability of …

The aim of the HERITAGE Family Study was to investigate individual differences in response
to a standardized endurance exercise program, the role of familial aggregation, and the …

Chronic musculoskeletal pain affects all aspects of human life. However, mechanisms of its
genetic control remain poorly understood. Genetic studies of pain are complicated by the …

Background Mildly elevated bilirubin, a by-product of hemoglobin breakdown, might mitigate
cardiometabolic risk factors including adiposity, dyslipidemia, and high blood pressure (BP) …

It remains unknown whether adiposity subtypes are differentially associated with colorectal
cancer (CRC). To move beyond single-trait anthropometric indicators, we derived four multi …