Covalent DNA–protein crosslinks (DPCs) are pervasive DNA lesions that interfere with
essential chromatin processes such as transcription or replication. This review strives to …

Hypoparathyroidism is a disease characterized by inadequately low circulating
concentrations of parathyroid hormone (PTH) resulting in low calcium levels and increased …

Zoonotic poxviruses such as mpox virus (MPXV) continue to threaten public health safety
since the eradication of smallpox. Vaccinia virus (VACV), the prototypic poxvirus used as the …

Magnesium is essential to the proper functioning of numerous cellular processes.
Magnesium ion (Mg 2+) deficits, as reflected in hypomagnesemia, can cause neuromuscular …

Objective: The epidemiology of hypoparathyroidism (HP) is largely unknown. We aimed to
determine prevalence, etiologies, health related quality of life (HRQOL) and treatment …

Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …

Cortical bone structure is a crucial determinant of bone strength, yet for many years studies
of novel genes and cell signalling pathways regulating bone strength have focused on the …

Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and
tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the …

Classical 'one-gene/one-disease'models cannot fully reconcile with the increasingly
appreciated prevalence of complicated genotype-to-phenotype associations in human …

Proteolysis plays fundamental and regulatory roles in diverse cellular processes. The serine
protease FAM111A (FAM111 trypsin-like peptidase A) emerged recently as a protease …