Molecular mechanisms of two-component signal transduction
CP Zschiedrich, V Keidel, H Szurmant - Journal of molecular biology, 2016 - Elsevier
Two-component systems (TCS) comprising sensor histidine kinases and response regulator
proteins are among the most important players in bacterial and archaeal signal transduction …
proteins are among the most important players in bacterial and archaeal signal transduction …
Identification of direct residue contacts in protein–protein interaction by message passing
Understanding the molecular determinants of specificity in protein–protein interaction is an
outstanding challenge of postgenome biology. The availability of large protein databases …
outstanding challenge of postgenome biology. The availability of large protein databases …
Interaction fidelity in two-component signaling
H Szurmant, JA Hoch - Current opinion in microbiology, 2010 - Elsevier
Two component signal transduction systems and phosphorelays have been adapted and
amplified by bacteria to respond to a multitude of environmental, metabolic and cell cycle …
amplified by bacteria to respond to a multitude of environmental, metabolic and cell cycle …
High-resolution protein complexes from integrating genomic information with molecular simulation
Bacteria use two-component signal transduction systems (TCS) extensively to sense and
react to external stimuli. In these, a membrane-bound sensor histidine kinase (SK) …
react to external stimuli. In these, a membrane-bound sensor histidine kinase (SK) …
Asymmetric cross‐regulation between the nitrate‐responsive NarX–NarL and NarQ–NarP two‐component regulatory systems from Escherichia coli K‐12
CE Noriega, HY Lin, LL Chen… - Molecular …, 2010 - Wiley Online Library
Summary The NarX–NarL and NarQ–NarP sensor–response regulator pairs control
Escherichia coli gene expression in response to nitrate and nitrite. Previous analysis …
Escherichia coli gene expression in response to nitrate and nitrite. Previous analysis …
Inferring interaction partners from protein sequences using mutual information
AF Bitbol - PLoS computational biology, 2018 - journals.plos.org
Functional protein-protein interactions are crucial in most cellular processes. They enable
multi-protein complexes to assemble and to remain stable, and they allow signal …
multi-protein complexes to assemble and to remain stable, and they allow signal …
Using structural information to change the phosphotransfer specificity of a two-component chemotaxis signalling complex
Two-component signal transduction pathways comprising histidine protein kinases (HPKs)
and their response regulators (RRs) are widely used to control bacterial responses to …
and their response regulators (RRs) are widely used to control bacterial responses to …
Inference of direct residue contacts in two-component signaling
Since the onset of the genomic era more than 1000 bacterial genomes have been
sequenced and several fold more are expected to be completed in the near future. These …
sequenced and several fold more are expected to be completed in the near future. These …
The histidine kinase inhibitor Sda binds near the site of autophosphorylation and may sterically hinder autophosphorylation and phosphotransfer to Spo0F
KA Cunningham, WF Burkholder - Molecular microbiology, 2009 - Wiley Online Library
Histidine kinases are widely used by bacteria, fungi and plants to sense and respond to
changing environmental conditions. Signals in addition to those directly sensed by the …
changing environmental conditions. Signals in addition to those directly sensed by the …
Blue light regulated two-component systems: enzymatic and functional analyses of light-oxygen-voltage (LOV)-histidine kinases and downstream response regulators
Light is an essential environmental cue for diverse organisms. Many prokaryotic blue light
photoreceptors use light, oxygen, voltage (LOV) sensory domains to control the activities of …
photoreceptors use light, oxygen, voltage (LOV) sensory domains to control the activities of …