Targeting TGF-β signal transduction for fibrosis and cancer therapy

D Peng, M Fu, M Wang, Y Wei, X Wei - Molecular cancer, 2022 - Springer
Transforming growth factor β (TGF-β) has long been identified with its intensive involvement
in early embryonic development and organogenesis, immune supervision, tissue repair, and …

The dynamic nature of senescence in cancer

S Lee, CA Schmitt - Nature cell biology, 2019 - nature.com
Cellular senescence is implicated in physiological and pathological processes spanning
development, wound healing, age-related decline in organ functions and cancer. Here, we …

Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases

SM Lagoumtzi, N Chondrogianni - Free Radical Biology and Medicine, 2021 - Elsevier
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and
environmental factors, characterizing many types of somatic cells. It has been suggested as …

Senescence rewires microenvironment sensing to facilitate antitumor immunity

HA Chen, YJ Ho, R Mezzadra, JM Adrover, R Smolkin… - Cancer discovery, 2023 - AACR
Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that,
in some instances, stimulates the immune clearance of senescent cells. Using an immune …

Senescence of alveolar type 2 cells drives progressive pulmonary fibrosis

C Yao, X Guan, G Carraro, T Parimon, X Liu… - American journal of …, 2021 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung
disease associated with declining pulmonary function. Accelerated aging, loss of epithelial …

TGF-β signaling in cellular senescence and aging-related pathology

K Tominaga, HI Suzuki - International journal of molecular sciences, 2019 - mdpi.com
Aging is broadly defined as the functional decline that occurs in all body systems. The
accumulation of senescent cells is considered a hallmark of aging and thought to contribute …

Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence via the interferon protein IFITM3

M Borghesan, J Fafián-Labora, O Eleftheriadou… - Cell Reports, 2019 - cell.com
Senescence is a cellular phenotype present in health and disease, characterized by a stable
cell-cycle arrest and an inflammatory response called senescence-associated secretory …

Classical and nonclassical intercellular communication in senescence and ageing

JA Fafián-Labora, A O'Loghlen - Trends in cell biology, 2020 - cell.com
Intercellular communication refers to the different ways through which cells communicate
with each other and transfer a variety of messages. These communication methods involve a …

[HTML][HTML] The role of cellular senescence in skin aging and age-related skin pathologies

T Chin, Y Lee, O Dreesen - Frontiers in physiology, 2023 - frontiersin.org
Aging is the result of a gradual functional decline at the cellular, and ultimately, organismal
level, resulting in an increased risk of developing a variety of chronic illnesses, such as …

Cellular senescence and ageing: mechanisms and interventions

A Mylonas, A O'Loghlen - Frontiers in Aging, 2022 - frontiersin.org
The influence of the activation of a cellular phenotype termed senescence and it's
importance in ageing and age-related diseases is becoming more and more evident. In fact …