Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

Rationale: The heart undergoes dramatic developmental changes during the prenatal to
postnatal transition, including maturation of cardiac myocyte energy metabolic and …

Cardiomyocytes undergo significant structural and functional changes after birth, and these
fundamental processes are essential for the heart to pump blood to the growing body …

Heart failure remains a significant cause of morbidity and mortality following myocardial
infarction. Cardiac remuscularization with transplantation of human pluripotent stem cell …

In mammals, most cardiomyocytes (CMs) become polyploid (they have more than two
complete sets of chromosomes). The purpose of this review is to evaluate assumptions …

Mitochondria are the main site of intracellular synthesis of ATP, which provides energy for
various physiological activities of the cell. Cardiomyocytes have a high density of …

The postnatal mammalian heart undergoes remarkable developmental changes, which are
stimulated by the transition from the intrauterine to extrauterine environment. With birth …

Abstract Knowledge about the molecular mechanisms regulating cardiomyocyte (CM)
proliferation and differentiation has increased exponentially in recent years. Such insights …

Organoids, or miniaturized organs formed in vitro, hold potential to revolutionize how
researchers approach and answer fundamental biological and pathological questions. In the …