The plasma membrane (PM) is the biological membrane that separates the interior of all
cells from the outside. The PM is constituted of a huge diversity of proteins and lipids. In this …

Sterols, which are isoprenoid derivatives, are structural components of biological
membranes. Special attention is now being given not only to their structure and function, but …

Endosomal sequestration of lipid-based nanoparticles (LNPs) remains a formidable barrier
to delivery. Herein, structure-activity analysis of cholesterol analogues reveals that …

Cholesterol plays a strategic role in liposome composition; however, the quantity used to
achieve an appropriate formulation has not been yet clarified. Therefore, by screening …

Without any exaggeration, cholesterol is one of the most important lipid species in eukaryotic
cells. Its effects on cellular membranes and functions range from purely mechanistic to …

The aim of this study was to substitute part of soybean phospholipid (SPC) with
hydrogenated soybean phospholipid (HSPC) in curcumin-loaded liposomes (Cur-LP), in …

To be able to model complex biological membranes in a more realistic manner, the force
field Slipids (Stockholm lipids) has been extended to include parameters for sphingomyelin …

In this work, the effect of β-sitosterol (Sito) on vesicle characteristics, physicochemical
stability as well as the in vitro release and bioavailability of curcumin-loaded liposomes (Cur …

Molecular simulations of lipids and surfactants require accurate parameters to reproduce
and predict experimental properties. Previously, a united atom (UA) chain model was …

A modification of the CHARMM36 lipid force field (C36) for cholesterol, henceforth, called
C36c, is reported. A fused ring compound, decalin, was used to model the steroid section of …