General anesthetics depress excitatory and/or enhance inhibitory synaptic transmission
principally by modulating the function of glutamatergic or GABAergic synapses, respectively …

This document reviews the literature on local brain manipulation of general anesthesia in
animals, focusing on behavioral and electrographic effects related to hypnosis or loss of …

Urethane is widely used in neurophysiological experiments to anesthetize animals, yet little
is known about its actions at the cellular and synaptic levels. This limits our ability to model …

Identifying presynaptic mechanisms of general anesthetics is critical to understanding their
effects on synaptic transmission. We show that the volatile anesthetic isoflurane inhibits …

General anesthetics are a class of drugs that target the central nervous system and are
widely used for various medical procedures. General anesthetics produce many behavioral …

POCD describes a decline in cognitive function after surgery with a predominance in the
elderly patient. Although there is general agreement that POCD is likely to be multifactorial, it …

The majority of sensory physiology experiments have used anesthesia to facilitate the
recording of neural activity. Current techniques allow researchers to study sensory function …

General anaesthetics act in an agent-specific manner on synaptic transmission in the central
nervous system by enhancing inhibitory transmission and reducing excitatory transmission …

BACKGROUND: Anesthetics enhance γ-aminobutyric acid (GABA)-mediated inhibition in
the central nervous system. Different agents have been shown to act on tonic versus …

Examination of volatile anesthetic actions at single synapses provides more direct
information by reducing interference by surrounding tissue and extrasynaptic modulation …