Importance Pulmonary embolism (PE) is characterized by occlusion of blood flow in a
pulmonary artery, typically due to a thrombus that travels from a vein in a lower limb. The …

determination and the implementation of preventive, diagnostic or therapeutic medical
strategies. However, the ESC Guidelines do not override in any way whatsoever the …

Abstract Background Over 5,488,000 cases of coronavirus disease-19 (COVID-19) have
been reported since December 2019. We aim to explore risk factors associated with …

Clinical prediction models aim to predict outcomes in individuals, to inform diagnosis or
prognosis in healthcare. Hundreds of prediction models are published in the medical …

Background Clinical prediction models should be validated before implementation in clinical
practice. But is favorable performance at internal validation or one external validation …

When designing a study to develop a new prediction model with binary or time‐to‐event
outcomes, researchers should ensure their sample size is adequate in terms of the number …

COVID-19, the disease responsible for the devastating pandemic that began at the end of
2019, has been associated with a significantly increased risk of pulmonary thrombosis, even …

Deep vein thrombosis and pulmonary embolism, collectively referred to as venous
thromboembolism, constitute a major global burden of disease. The diagnostic work-up of …

Background Retrospective analyses suggest that pulmonary embolism is ruled out by a d-
dimer level of less than 1000 ng per milliliter in patients with a low clinical pretest probability …

The TRIPOD (Transparent Reporting of a multivariable prediction model for Individual
Prognosis Or Diagnosis) Statement includes a 22-item checklist, which aims to improve the …