Atrial fibrillation (AF), the most prevalent arrhythmia, is often associated with enhanced
inflammatory response. Emerging evidence points to a causal role of inflammatory signaling …

Heart failure (HF) with preserved ejection fraction (HFpEF) is currently the predominant form
of HF with a dramatic increase in risk with age. Low‐grade inflammation, as occurs with …

Chronic kidney disease (CKD) is a significant worldwide healthcare problem. Regardless of
the initial injury, renal fibrosis is the common final pathway leading to end stage renal …

It is well established that adipose tissue, apart from its energy storage function, acts as an
endocrine organ that produces and secretes a number of bioactive substances, including …

Atrial fibrillation (AF), the most common progressive and age-related cardiac arrhythmia,
affects millions of people worldwide. AF is associated with common risk factors, including …

Cardiovascular fibrosis refers to the scar tissue that develops in the injured heart and blood
vessels from an aberrant wound healing response to organ injury or insult. Established …

While ischemia itself can kill heart muscle, much of the infarction after a transient period of
coronary artery occlusion has been found to result from injury during reperfusion. Here we …

Background NLRP3 inflammasome activation and pyroptosis play a significant role in
myocardial ischemia reperfusion injury (MI/RI). Geniposide was reported to show potential …

Aims The aim of this study was to investigate the cardioprotective effects of ghrelin against
myocardial ischemia/reperfusion (I/R) injury and the underlying mechanism. Main methods …

Fibrosis is associated with accumulation of excess fibrillar collagen, leading to tissue
dysfunction. Numerous processes, including inflammation, myofibroblast activation, and …