Malignant transformation is characterized by dysregulation of diverse cellular processes that
have been the subject of detailed genetic, biochemical, and structural studies, but only …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

The MYC proto-oncogene has been implicated in the pathogenesis of most types of human
tumors. MYC activation alone in many normal cells is restrained from causing tumorigenesis …

Gastric cancer (GC) is globally the fifth most common cancer and third leading cause of
cancer death. A complex disease arising from the interaction of environmental and host …

Abstract Sp1 (specificity protein 1) is a well-known member of a family of transcription factors
that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer
and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be …

Yes-associated protein (YAP) and its paralog, transcriptional coactivator with PDZ-binding
motif (TAZ), play pivotal roles in promoting the progression of hepatocellular carcinoma …

Glioblastoma is the most common and most aggressive primary brain malignancy. The
current initial standard of care consists of maximal safe surgical resection followed by radical …

The coactivator associated arginine methyltransferase (CARM1) promotes transcription, as
its name implies. It does so by modifying histones and chromatin bound proteins. We …