During the last two decades, research into the modulation of immunity by the
neuroendocrine system has flourished, unravelling significant effects of several …

The gene expression profile of metastasizing serotonin-producing neuroendocrine
carcinomas, which arise from enterochromaffin cells in the jejunum and ileum, is still largely …

Tryptophan hydroxylases catalyze the first and rate-limiting step in the synthesis of
serotonin. Serotonin is a key neurotransmitter in the central nervous system and, in the …

Current classifications of human gastroenteropancreatic neuroendocrine tumors (NETs) are
inconsistent and based upon histopathologic but not molecular features. We sought to …

Accurate quantitation of target genes depends on correct normalization. Use of genes with
variable tissue transcription (GAPDH) is problematic, particularly in clinical samples, which …

Eur J Clin Invest 2011; 41 (12): 1353–1360 Abstract Endocrine tumours derived from the
small intestine, ileal carcinoids, produce and secrete the hormones tachykinins and …

Octreotide is a widely used synthetic somatostatin analogue that significantly improves the
management of neuroendocrine tumours (NETs). Octreotide acts through somatostatin …

Enterochromaffin (EC) cells in the gastrointestinal (GI) mucosa are the main source of
serotonin (5-hydroxytryptamine (5-HT)) in the body. 5-HT is implicated in the …

Introduction. Our aim was to investigate the immune status of midgut carcinoid patients.
Cancer patients generally display suppressed Th1-type immunity that disables mounting of …

Background: Neuroendocrine tumors (NETs) of the gastrointestinal (GI) system are
increasing in incidence with minimal improvement in prognosis. Although the cell of origin …