Nonadherence or nonpersistence to intravitreal injection therapy for neovascular age-related macular degeneration: a mixed-methods systematic review

M Okada, P Mitchell, RP Finger, B Eldem, SJ Talks… - Ophthalmology, 2021 - Elsevier
Topic Systematic review of risk factors for nonadherence and nonpersistence to intravitreal
anti–vascular endothelial growth factor (VEGF) injection therapy for neovascular age-related …

Undertreatment of neovascular age-related macular degeneration after 10 years of anti-vascular endothelial growth factor therapy in the real world: the need for a …

J Monés, RP Singh, F Bandello, E Souied, X Liu… - …, 2020 - karger.com
Purpose: To assess the gap between visual acuity (VA) outcomes with anti-vascular
endothelial growth factor (anti-VEGF) therapies in clinical trials and real-world practice, and …

[HTML][HTML] HAWK and HARRIER: phase 3, multicenter, randomized, double-masked trials of brolucizumab for neovascular age-related macular degeneration

PU Dugel, A Koh, Y Ogura, GJ Jaffe, U Schmidt-Erfurth… - Ophthalmology, 2020 - Elsevier
Purpose Two similarly designed phase 3 trials (HAWK and HARRIER) compared
brolucizumab, a single-chain antibody fragment that inhibits vascular endothelial growth …

Short-term real-world outcomes following intravitreal brolucizumab for neovascular AMD: SHIFT study

LM Bulirsch, M Saßmannshausen, J Nadal… - British Journal of …, 2022 - bjo.bmj.com
Background Brolucizumab has recently been approved in Europe as a novel treatment for
patients with neovascular age-related macular degeneration (nAMD). We report on early …

Association of treatment adherence with real-life VA outcomes in AMD, DME, and BRVO patients

C Ehlken, M Helms, D Böhringer… - Clinical …, 2017 - Taylor & Francis
Purpose Real-life clinical outcomes of patients treated with anti-VEGF drugs for neovascular
age-related macular degeneration (nAMD), diabetic macular edema (DME), or macular …

Preclinical evaluation of ADVM-022, a novel gene therapy approach to treating wet age-related macular degeneration

R Grishanin, B Vuillemenot, P Sharma, A Keravala… - Molecular Therapy, 2019 - cell.com
Inhibition of vascular endothelial growth factor, a key contributor to the choroidal
neovascularization associated with wet age-related macular degeneration, is the mode of …

Intravitreal aflibercept 8 mg in neovascular age-related macular degeneration (PULSAR): 48-week results from a randomised, double-masked, non-inferiority, phase 3 …

P Lanzetta, JF Korobelnik, JS Heier, S Leal, FG Holz… - The Lancet, 2024 - thelancet.com
Background Intravitreal aflibercept 8 mg could improve treatment outcomes and provide
sustained disease control in patients with neovascular age-related macular degeneration …

Loss to follow-up among patients with neovascular age-related macular degeneration who received intravitreal anti–vascular endothelial growth factor injections

A Obeid, X Gao, FS Ali, CM Aderman… - JAMA …, 2018 - jamanetwork.com
Importance Loss to follow-up (LTFU) after anti–vascular endothelial growth factor (anti-
VEGF) injections increases the risk of vision loss among patients with neovascular age …

Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side

M Hudecek, Z Izsvák, S Johnen, M Renner… - Critical reviews in …, 2017 - Taylor & Francis
Molecular medicine has entered a high-tech age that provides curative treatments of
complex genetic diseases through genetically engineered cellular medicinal products. Their …

Delayed follow-up of medical retina patients due to COVID-19: impact on disease activity and visual acuity

LG Stone, ME Grinton, JS Talks - Graefe's Archive for Clinical and …, 2021 - Springer
Purpose The coronavirus pandemic has prompted unprecedented delays to treatment with
anti-VEGF intravitreal injections due to the need to reduce hospital attendances and …