Hepatitis C virus (HCV) infection is a worldwide public health problem. Chronic infection with
HCV can lead to liver cirrhosis or cancer. Although some immune-competent individuals can …

The NLRP3 inflammasome's core and most specific protein, NLRP3, has a variety of
functions in inflammation-driven diseases. Costunolide (COS) is the major active ingredient …

The drug–drug interaction studies for HCV direct-acting antivirals and antiretrovirals are
important in determining the appropriate drug combinations and dosages. The clinical …

Alectinib, an anaplastic lymphoma kinase (ALK) inhibitor, is approved for treatment of
patients with ALK+ non–small cell lung cancer who have progressed, on or are intolerant to …

Advances in understanding of human disease have prompted the US Food and Drug
Administration to classify certain molecules as “break-through therapies,” providing an …

Ethnopharmacological relevance Spica prunellae (SP) is a well-known traditional Chinese
medicinal herb with properties of antihypertensive, antihyperglycemic, antiviral, anti …

Background Cost-utility analyses are frequently conducted to compare treatments for
hepatitis C, which are often associated with complex regimens and serious adverse events …

Vemurafenib is an orally bioavailable BRAF inhibitor approved for the treatment of
BRAFV600‐mutant metastatic melanoma. It is important to understand the effects of a high …

Abstract Ethnopharmacological relevance Astragali radix (“Huang Qi” in Chinese, HQ) is a
well-known traditional Chinese herbal medicine that possesses various biological functions …

Previously, we found that telaprevir (Tel), the inhibitor of hepatitis C virus NS3/4A serine
protease, reduces estrogen receptor α (ERα) content at the transcriptional level without …