Autoantibodies in systemic lupus erythematosus: From immunopathology to therapeutic target

H Lou, GS Ling, X Cao - Journal of autoimmunity, 2022 - Elsevier
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple
organ inflammatory damage and wide spectrum of autoantibodies. The autoantibodies …

The pathogenesis of lupus nephritis

M Lech, HJ Anders - Journal of the American Society of …, 2013 - journals.lww.com
Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE.
The pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The …

Beyond tissue injury—damage-associated molecular patterns, Toll-like receptors, and inflammasomes also drive regeneration and fibrosis

HJ Anders, L Schaefer - Journal of the American Society of …, 2014 - journals.lww.com
Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …

From systemic lupus erythematosus to lupus nephritis: The evolving road to targeted therapies

M Xipell, GM Lledó, AC Egan, F Tamirou… - Autoimmunity …, 2023 - Elsevier
Systemic lupus erythematosus is a chronic autoimmune disease characterized by loss of
tolerance against nuclear and cytoplasmic self-antigens, induction of immunity and tissue …

Mechanisms of tissue injury in lupus nephritis

TK Nowling, GS Gilkeson - Arthritis research & therapy, 2011 - Springer
Systemic lupus erythematosus is a prototypic autoimmune disease characterized by
autoantibody production and immune complex formation/deposition in target organs such as …

Cellular aspects of the pathogenesis of lupus nephritis

A Chang, MR Clark, K Ko - Current opinion in rheumatology, 2021 - journals.lww.com
Cellular aspects of the pathogenesis of lupus nephritis : Current Opinion in Rheumatology
Cellular aspects of the pathogenesis of lupus nephritis : Current Opinion in Rheumatology Log …

The pathogenesis and diagnosis of systemic lupus erythematosus: still not resolved

OP Rekvig, J Van der Vlag - Seminars in immunopathology, 2014 - Springer
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with various clinical
manifestations affecting different tissues. A characteristic feature of SLE is the presence of …

[HTML][HTML] Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice

MR Krishnan, C Wang, TN Marion - Kidney international, 2012 - Elsevier
The strongest serological correlate for lupus nephritis is antibody to double-stranded DNA,
although the mechanism by which anti-DNA antibodies initiate lupus nephritis is unresolved …

Pathogenesis of renal disease in systemic lupus erythematosus—the role of autoantibodies and lymphocytes subset abnormalities

DYH Yap, KN Lai - International journal of molecular sciences, 2015 - mdpi.com
Lupus nephritis (LN) is a common and severe organ manifestation of systemic lupus
erythematosus (SLE), and is associated with significant patient morbidity and mortality …

Autoantibodies and resident renal cells in the pathogenesis of lupus nephritis: getting to know the unknown

S Yung, TM Chan - Journal of Immunology Research, 2012 - Wiley Online Library
Systemic lupus erythematosus is characterized by a breakdown of self‐tolerance and
production of autoantibodies. Kidney involvement (ie, lupus nephritis) is both common and …