Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …

Inhibition of immune regulatory checkpoints, such as CTLA-4 and the PD-1-PD-L1 axis, is at
the forefront of immunotherapy for cancers of various histological types. However, such …

The majority of monoclonal antibody (mAb) therapeutics possess the ability to engage
innate immune effectors through interactions mediated by their fragment crystallizable (Fc) …

Fc receptors (FcRs) belong to the ITAM-associated receptor family. FcRs control the humoral
and innate immunity which are essential for appropriate responses to infections and …

Crohn's disease and ulcerative colitis, collectively known as IBD, are chronic inflammatory
disorders of the gastrointestinal tract. Although the aetiopathogenesis of IBD is largely …

Meta-analysis is pervasively used to combine multiple genome-wide association studies
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …

Activation of the humoral immune system is initiated when antibodies recognize an antigen
and trigger effector functions through the interaction with Fc engaging molecules. The most …

Therapeutic monoclonal antibodies (mAbs) have become one of the fastest growing classes
of drugs in recent years and are approved for the treatment of a wide range of indications …

Immunoglobulins G (IgG) and their Fc gamma receptors (FcγRs) play important roles in our
immune system. The conserved N-glycan in the Fc region of IgG1 impacts interaction of IgG …

IgG antibodies are actively produced in response to antigenic challenge or passively
administered as an effective form of immunotherapy to confer immunity against foreign …