Novel Ligands Targeting α4β1 Integrin: Therapeutic Applications and Perspectives

M Baiula, S Spampinato, L Gentilucci… - Frontiers in …, 2019 - frontiersin.org
Among the other members of the adhesion molecules' family, α4β1 integrin, a heterodimeric
receptor, plays a crucial role in inflammatory diseases, cancer development, metastasis and …

New agents in HSC mobilization

MJ Domingues, SK Nilsson, B Cao - International journal of hematology, 2017 - Springer
Mobilized peripheral blood (PB) is the most common source of hematopoietic stem cells
(HSC) for autologous transplantation. Granulocyte colony stimulating factor (G-CSF) is the …

Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist

B Cao, Z Zhang, J Grassinger, B Williams… - Nature …, 2016 - nature.com
The inherent disadvantages of using granulocyte colony-stimulating factor (G-CSF) for
hematopoietic stem cell (HSC) mobilization have driven efforts to identify alternate strategies …

Niche extracellular matrix components and their influence on HSC

MJ Domingues, H Cao, SY Heazlewood… - Journal of cellular …, 2017 - Wiley Online Library
Maintenance of hematopoietic stem cells (HSC) takes place in a highly specialized
microenvironment within the bone marrow. Technological improvements, especially in the …

Osteopontin is an important regulative component of the fetal bone marrow hematopoietic stem cell niche

H Cao, B Cao, CK Heazlewood, M Domingues, X Sun… - Cells, 2019 - mdpi.com
Osteopontin (OPN) is an important component in both bone and blood regulation,
functioning as a bridge between the two. Previously, thrombin-cleaved osteopontin (trOPN) …

α4/α9 integrins coordinate epithelial cell migration through local suppression of MAP kinase signaling pathways

W Hight-Warburton, R Felix, A Burton… - Frontiers in Cell and …, 2021 - frontiersin.org
Adhesion of basal keratinocytes to the underlying extracellular matrix (ECM) plays a key role
in the control of skin homeostasis and response to injury. Integrin receptors indirectly link the …

Fluorescent visualization of Src by using dasatinib‐BODIPY

ML Vetter, Z Zhang, S Liu, J Wang, HY Cho… - …, 2014 - Wiley Online Library
Many biological experiments are not compatible with the use of immunofluorescence,
genetically encoded fluorescent tags, or FRET‐based reporters. Conjugation of existing …

Rearrangement of Threonine- and Serine-Based N-(3-Phenylprop-2-yn-1-yl) Sulfonamides Yields Chiral Pyrrolidin-3-ones

P Králová, M Maloň, J Pospíšil… - The Journal of Organic …, 2019 - ACS Publications
N-(3-Phenylprop-2-yn-1-yl)-sulfonamides derived from serine and threonine were
synthesized using solid-phase synthesis and subjected to reaction with trimethylsilyl …

The importance of selection and reporting of the sex of experimental animals

A Rowe - Animal Production Science, 2018 - CSIRO Publishing
Biased use of males and females in animal studies or omitting specific details of the sex of
animals used in publications limits reproducibility, hampers the pace and likelihood of new …

Acute lymphoblastic leukemia and the bone marrow microenvironment

CL Pritchard, SY Heazlewood, B Cao - Advances in Stem Cells and their …, 2021 - Elsevier
Acute lymphoblastic leukemia (ALL) remains the most common childhood cancer, and
despite the vast improvements to clinical treatments, relapse continues to be associated with …