Drug-induced hypersensitivity syndrome (DiHS), also known as drug reaction with
eosinophilia and systemic symptoms (DRESS), is a severe cutaneous adverse reaction …

Background Allopurinol is the primary therapy for the management of chronic gout.
Utilization of allopurinol has increased in tandem with the growing prevalence of gout …

Background Carbamazepine causes various forms of hypersensitivity reactions, ranging
from maculopapular exanthema to severe blistering reactions. The HLA-B* 1502 allele has …

Importance Antibiotics are an important risk for Stevens-Johnson syndrome and toxic
epidermal necrolysis (SJS/TEN), which are the most severe types of drug hypersensitivity …

Importance Allopurinol, a first-line drug used for treating gout, is increasingly prescribed
worldwide to patients with asymptomatic hyperuricemia and comorbid renal or …

Background Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is
a rare but severe hypersensitivity reaction that remains poorly characterized in the United …

Most immune-mediated adverse drug reactions (IM-ADRs) involve the skin, and many have
additional systemic features. Severe cutaneous adverse drug reactions (SCARs) are an …

Drug response varies between individuals owing to disease heterogeneity, environmental
factors, and genetic factors. Genetic factors can affect both the pharmacokinetics and …

Drug hypersensitivity reactions are an important clinical problem for both health care and
industry. Recent advances in genetics have identified a number of HLA alleles associated …

Background: Epidemiological data is limited for cutaneous adverse drug reactions (CADRs)
in India. Most of the Indian studies have small sample size and are of limited duration. Aims …