Review of in silico models of cerebral blood flow in health and pathology
In this review, we provide a summary of the state-of-the-art in the in silico modelling of
cerebral blood flow (CBF) and its application in in silico clinical trials. CBF plays a key role in …
cerebral blood flow (CBF) and its application in in silico clinical trials. CBF plays a key role in …
Computation of two-dimensional stokes flows via lightning and AAA rational approximation
Low Reynolds number fluid flows are governed by the Stokes equations. In two dimensions,
Stokes flows can be described by two analytic functions, known as Goursat functions …
Stokes flows can be described by two analytic functions, known as Goursat functions …
[HTML][HTML] Human whole-brain models of cerebral blood flow and oxygen transport
The cerebral vasculature plays a critical role in the transport of oxygen and other nutrients to
brain tissue. However, the size, complexity, and paucity of detailed anatomical information of …
brain tissue. However, the size, complexity, and paucity of detailed anatomical information of …
Computation of 2D Stokes flows via lightning and AAA rational approximation
Low Reynolds number fluid flows are governed by the Stokes equations. In two dimensions,
Stokes flows can be described by two analytic functions, known as Goursat functions …
Stokes flows can be described by two analytic functions, known as Goursat functions …
A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes
Vascular pathology is associated with cognitive impairment in diseases such as type 1
diabetes; however, how capillary flow is affected and the underlying mechanisms remain …
diabetes; however, how capillary flow is affected and the underlying mechanisms remain …
[HTML][HTML] Parameter quantification for oxygen transport in the human brain
Background and objective: Oxygen is carried to the brain by blood flow through generations
of vessels across a wide range of length scales. This multi-scale nature of blood flow and …
of vessels across a wide range of length scales. This multi-scale nature of blood flow and …
Modeling oxygen transport in the brain: An efficient coarse-grid approach to capture perivascular gradients in the parenchyma
D Pastor-Alonso, M Berg, F Boyer… - PLoS Computational …, 2024 - journals.plos.org
Recent progresses in intravital imaging have enabled highly-resolved measurements of
periarteriolar oxygen gradients (POGs) within the brain parenchyma. POGs are increasingly …
periarteriolar oxygen gradients (POGs) within the brain parenchyma. POGs are increasingly …
[HTML][HTML] Perivascular clearance of blood proteins after blood-brain barrier disruption in a rat model of microinfarcts
T Georgakopoulou, AE Van der Wijk, E van Bavel… - Microvascular …, 2023 - Elsevier
Microinfarcts result in a transient loss of the blood-brain barrier (BBB) in the ischemic
territory. This leads to the extravasation of blood proteins into the brain parenchyma. It is not …
territory. This leads to the extravasation of blood proteins into the brain parenchyma. It is not …
Modelling midline shift and ventricle collapse in cerebral oedema following acute ischaemic stroke
In ischaemic stroke, a large reduction in blood supply can lead to the breakdown of the
blood-brain barrier and to cerebral oedema after reperfusion therapy. The resulting fluid …
blood-brain barrier and to cerebral oedema after reperfusion therapy. The resulting fluid …
Stokes flows in a two-dimensional bifurcation
The flow network model is an established approach to approximate pressure–flow
relationships in a bifurcating network, and has been widely used in many contexts. Existing …
relationships in a bifurcating network, and has been widely used in many contexts. Existing …