Transforming growth factor-beta1 (TGF-β1), a key member in the TGF-β superfamily, plays a
critical role in the development of hepatic fibrosis. Its expression is consistently elevated in …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

In addition to genetic predisposition, environmental and lifestyle factors contribute to the
pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for …

Genome-wide association studies (GWAS) have defined over 150 genomic regions
unequivocally containing variation predisposing to immune-mediated disease. Inferring …

Circular RNAs (circRNAs) are an abundant class of endogenous non‑coding RNAs and are
associated with numerous diseases, including cancer, cardiovascular diseases, and type 2 …

The molecular pathways that govern human disease consist of molecular circuits that
coalesce into complex, overlapping networks. These network pathways are presumably …

The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …

With the advent of recent next-generation sequencing (NGS) technologies in genomics,
transcriptomics, and epigenomics, profiling single-cell sequencing became possible. The …

Diabetic nephropathy (DN) is a major diabetic complication. Transforming growth factor-β
(TGF-β) is a key mediator in the development of diabetic complications. It is well known that …

Characterizing, describing, and extracting information from a network is by now one of the
main goals of science, since the study of network currently draws the attention of several …