The BCL-2 family of proteins controls cell death primarily by direct binding interactions that
regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible …

During apoptotic cell death, cellular stress signals converge at the mitochondria to induce
mitochondrial outer-membrane permeabilization (MOMP) through B cell lymphoma-2 (BCL …

Many peptide hormones form an α-helix on binding their receptors,,–, and sensitive methods
for their detection could contribute to better clinical management of disease. De novo protein …

The BH3-only proteins of Bcl-2 family are essential initiators of apoptosis that propagate
extrinsic and intrinsic cell death signals. The interaction of BH3-only proteins with other Bcl-2 …

The myeloid leukemia cell differentiation protein (Mcl-1) is an anti-apoptotic protein of the B-
cell lymphoma 2 (Bcl-2) family, which regulates cellular apoptosis. Mcl-1 expression plays a …

Apoptosis is a biological process that removes damaged, excess or infected cells through a
genetically controlled mechanism. This process plays a crucial role in organismal …

Cancer is amongst the deadliest and most disruptive disorders, having a much higher death
rate than other diseases worldwide. Human cancer rates continue to rise, thereby posing the …

Bcl-2 family proteins regulate a critical step in apoptosis referred to as mitochondrial outer
membrane permeabilization (MOMP). Members of a subgroup of the Bcl-2 family, known as …

Cancer cells hijack BCL-2 family survival proteins to suppress the death effectors and
thereby enforce an immortal state. This is accomplished biochemically by an antiapoptotic …

Programmed cell death is a tightly controlled process critical for the removal of damaged or
infected cells. Pro-and antiapoptotic proteins of the Bcl-2 family are pivotal mediators of this …