The emerging role of histologic disease activity assessment in ulcerative colitis

RK Pai, V Jairath, NV Casteele, F Rieder… - Gastrointestinal …, 2018 - Elsevier
Background and Aims Assessment of disease activity is essential for developing and
determining appropriate therapy in patients with ulcerative colitis (UC). Validated clinical …

Predicting colorectal cancer occurrence in IBD

M Yalchin, AM Baker, TA Graham, A Hart - Cancers, 2021 - mdpi.com
Simple Summary Patients with inflammatory bowel disease are at an increased risk of
developing colorectal cancer, and so are enrolled in a surveillance colonoscopy programme …

Single-cell analyses of colon and blood reveal distinct immune cell signatures of ulcerative colitis and Crohn's disease

V Mitsialis, S Wall, P Liu, J Ordovas-Montanes… - Gastroenterology, 2020 - Elsevier
Background & Aims Studies are needed to determine the mechanisms of mucosal
dysregulation in patients with inflammatory bowel diseases (IBDs) and differences in …

ECCO position paper: harmonization of the approach to ulcerative colitis histopathology

F Magro, G Doherty, L Peyrin-Biroulet… - Journal of Crohn's …, 2020 - academic.oup.com
Currently, the main targets of drug therapy for ulcerative colitis [UC] are endoscopic and
clinical remission. However, there is active discussion about the additional advantages of …

Combination of probiotics with different functions alleviate DSS-induced colitis by regulating intestinal microbiota, IL-10, and barrier function

Y Wang, Q Xie, Y Zhang, W Ma, K Ning… - Applied microbiology …, 2020 - Springer
The potential of probiotics for treating ulcerative colitis (UC) has attracted increasing
attention. However, more studies are still needed to guide physicians on the proper …

[HTML][HTML] Relationship between combined histologic and endoscopic endpoints and efficacy of ustekinumab treatment in patients with ulcerative colitis

K Li, C Marano, H Zhang, F Yang, WJ Sandborn… - Gastroenterology, 2020 - Elsevier
Background & Aims Ustekinumab induces and maintains histologic improvement in patients
with ulcerative colitis (UC). The clinical relevance of this endpoint alone, and in combination …

Comparison of different histological indexes in the assessment of UC activity and their accuracy regarding endoscopic outcomes and faecal calprotectin levels

F Magro, J Lopes, P Borralho, S Lopes, R Coelho… - Gut, 2019 - gut.bmj.com
Objective Histological remission is being increasingly acknowledged as a therapeutic
endpoint in patients with UC. The work hereafter described aimed to evaluate the …

3D printed tacrolimus rectal formulations ameliorate colitis in an experimental animal model of inflammatory bowel disease

I Seoane-Viaño, N Gómez-Lado, H Lázare-Iglesias… - Biomedicines, 2020 - mdpi.com
The aim of this study was to fabricate novel self-supporting tacrolimus suppositories using
semisolid extrusion 3-dimensional printing (3DP) and to investigate their efficacy in an …

Composite assessment using intestinal ultrasound and calprotectin is accurate in predicting histological activity in ulcerative colitis: a cohort study

TM Goodsall, AS Day, JM Andrews… - Inflammatory Bowel …, 2024 - academic.oup.com
Background Beyond endoscopic remission, histological remission in ulcerative colitis (UC)
is predictive of clinical outcomes. Intestinal ultrasound (IUS) may offer a noninvasive …

[HTML][HTML] Artificial intelligence enables quantitative assessment of ulcerative colitis histology

F Najdawi, K Sucipto, P Mistry, S Hennek, CKB Jayson… - Modern Pathology, 2023 - Elsevier
Ulcerative colitis is a chronic inflammatory bowel disease that is characterized by a
relapsing and remitting course. Assessment of disease activity critically informs treatment …