Alternative splicing significantly enhances the diversity of the G protein-coupled receptor
(GPCR) family, including the histamine H3 receptor (H3R). This post-transcriptional …

Alcohol use disorder is associated with several mental, physical, and social problems. Its
treatment is difficult and often requires a combination of pharmacological and behavioural …

Recent evidence shows that the expression levels of histamine receptor H3 (Hrh3) are
upregulated in several types of cancer. However, the role of Hrh3 in non-small cell lung …

Background: The histamine-3 receptor (H3R) is an auto-and heteroreceptor that inhibits the
release of histamine and other neurotransmitters. Post-mortem evidence has found altered …

Background Histamine (HA), a wake-promoting monoamine implicated in stress-related
arousal states, is synthesized in histidine decarboxylase–expressing hypothalamic neurons …

Hyperfunction of the dopamine system has been implicated in manic episodes in bipolar
disorders. How dopaminergic neuronal function is regulated in the pathogenesis of mania …

Histamine H 3 receptors are widely distributed G i-coupled receptors whose activation
reduces neuronal activity and inhibits release of numerous neurotransmitters. Although …

Background The histamine-3 receptor (H3R) may have a role in cognitive processes through
its action as a presynaptic heteroreceptor inhibiting the release of glutamate in the brain. To …

Histamine and its receptors in the nervous system received recognition late in comparison to
the other aminergic transmitters, after the detection of histaminergic neurons in the posterior …

Ciproxifan is an H 3 receptor antagonist and inverse agonist with antipsychotic effects in
several preclinical models; its effect on glutamate release has been investigated in the rat …