Little is known about how the genotypic and molecular abnormalities associated with
epithelial cancers actually contribute to the histological phenotypes observed in tumours in …

This review focuses on remarkable recent findings concerning the mechanism by which the
LKB1 protein kinase that is mutated in Peutz-Jeghers cancer syndrome operates as a tumor …

INTRODUCTION Advances in DNA sequencing technology have enabled the widespread
analysis of breast tumor genomes, creating a catalog of genetic mutations that may initiate or …

Importance E-cadherin (CDH1) is a cancer predisposition gene mutated in families meeting
clinically defined hereditary diffuse gastric cancer (HDGC). Reliable estimates of cancer risk …

AMPK is a serine/threonine protein kinase, which serves as an energy sensor in all
eukaryotic cell types. Published studies indicate that AMPK activation strongly suppresses …

Peutz-Jeghers syndrome (PJS) is an autosomal dominant disease caused by germline
mutation of the serine threonine kinase 11 and characterized by hamartomatous polyps in …

The development of cancer is a multistep process in which the DNA of a single cell
accumulates mutations in genes that control essential cellular processes. Loss of cell–cell …

The LKB1-AMPK signaling pathway serves as a critical cellular sensor coupling energy
homeostasis to cell growth, proliferation, and survival. However, how tumor cells suppress …

Cancer is the result of the deregulation of cell proliferation and cell migration. In advanced
tumors, cells invade the surrounding tissue and eventually form metastases. This is …

Purpose: Radiotherapy with or without chemotherapy is a mainstay of treatment for locally
advanced non–small cell lung cancer (NSCLC), but no predictive markers are currently …