The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

Neuronal nicotinic receptors (NAChRs) form a heterogeneous family of ion channels that are
differently expressed in many regions of the central nervous system (CNS) and peripheral …

Neuronal nicotinic acetylcholine (nACh) receptors in the brain are more commonly
associated with modulatory events than mediation of synaptic transmission. nACh receptors …

Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …

The α7 subunit of the neuronal nicotinic acetylcholine receptor (nAChR) is abundantly
expressed in hippocampus and is implicated in modulating neurotransmitter release and in …

Until recently, research on (S)-(-)-nicotine (1, hereafter simply nicotine) and nicotinic
acetylcholine receptors (nAChRs) emphasized two principal aspects. The first was the …

Nicotinic acetylcholine receptors (AChRs) are a family of acetylcholine-gated cation
channels that form the predominant excitatory neurotransmitter receptors on muscles and …

France rather than the tertiary folding within each individual subunit. In other words, the
cooperative interactions The concept of allosteric proteins was initially proposed between …

Nicotine is a very widely used drug of abuse, which exerts a number of neurovegetative,
behavioural and psychological effects by interacting with neuronal nicotinic acetylcholine …

Alzheimer's disease produces a devastating decline in mental function, with profound effects
on learning and memory. Early consequences of the disease include the specific loss of …