Scutellaria baicalensis Georgi., a plant used in traditional Chinese medicine, has multiple
biological activities, including anti-inflammatory, antiviral, antitumor, antioxidant, and …

The coordinating role of nuclear factor erythroid-2-related factor 2 (Nrf2) in cellular function
is undeniable. Evidence indicates that this transcription factor exerts massive regulatory …

Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring
when there is an imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2 …

The gene expression program induced by NRF2 transcription factor plays a critical role in
cell defense responses against a broad variety of cellular stresses, most importantly …

The NRF2/KEAP1 pathway is a fundamental signaling cascade that controls multiple
cytoprotective responses through the induction of a complex transcriptional program that …

Successful pregnancy depends on precise molecular regulation of uterine physiology,
especially during the menstrual cycle. Deregulated oxidative stress (OS), often influenced by …

Turnover of the mitochondrial pool due to coordinated processes of mitochondrial
biogenesis and mitophagy is an important process in maintaining mitochondrial stability. An …

Mutations in the KEAP1–NRF2 (Kelch-like ECH-associated protein 1–nuclear factor-
erythroid 2 p45-related factor 2) pathway occur in up to a third of non–small cell lung cancer …

Sickle cell disease (SCD) is a monogenic inheritable disease characterized by severe
anemia, increased hemolysis, and recurrent, painful vaso-occlusive crises due to the …

Abstract Nuclear factor erythroid 2-like 2 (Nrf2) is a transcription factor participating in
response to cellular oxidative stress to maintain the redox balance. Generation of reactive …