[HTML][HTML] Diabetic retinopathy: current understanding, mechanisms, and treatment strategies

EJ Duh, JK Sun, AW Stitt - JCI insight, 2017 - ncbi.nlm.nih.gov
Diabetic retinopathy (DR) causes significant visual loss on a global scale. Treatments for the
vision-threatening complications of diabetic macular edema (DME) and proliferative diabetic …

[HTML][HTML] Mechanisms of macular edema: beyond the surface

A Daruich, A Matet, A Moulin, L Kowalczuk… - Progress in retinal and …, 2018 - Elsevier
Macular edema consists of intra-or subretinal fluid accumulation in the macular region. It
occurs during the course of numerous retinal disorders and can cause severe impairment of …

The progress in understanding and treatment of diabetic retinopathy

AW Stitt, TM Curtis, M Chen, RJ Medina… - Progress in retinal and …, 2016 - Elsevier
Diabetic retinopathy is the most frequently occurring complication of diabetes mellitus and
remains a leading cause of vision loss globally. Its aetiology and pathology have been …

Photoreceptor cells and RPE contribute to the development of diabetic retinopathy

D Tonade, TS Kern - Progress in retinal and eye research, 2021 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as
vascular disease, but work in the past years has shown abnormalities also in the neural …

Retinal damage induced by commercial light emitting diodes (LEDs)

I Jaadane, P Boulenguez, S Chahory, S Carré… - Free Radical Biology …, 2015 - Elsevier
Spectra of “white LEDs” are characterized by an intense emission in the blue region of the
visible spectrum, absent in daylight spectra. This blue component and the high intensity of …

Interactions of the choroid, Bruch's membrane, retinal pigment epithelium, and neurosensory retina collaborate to form the outer blood-retinal-barrier

MA Fields, LV Del Priore, RA Adelman… - Progress in retinal and …, 2020 - Elsevier
The three interacting components of the outer blood-retinal barrier are the retinal pigment
epithelium (RPE), choriocapillaris, and Bruch's membrane, the extracellular matrix that lies …

Interaction between microglia and retinal pigment epithelial cells determines the integrity of outer blood‐retinal barrier in diabetic retinopathy

DH Jo, JH Yun, CS Cho, JH Kim, JH Kim, CH Cho - Glia, 2019 - Wiley Online Library
Inner and outer blood‐retinal barriers (BRBs), mainly composed of retinal endothelial cells
and retinal pigment epithelial (RPE) cells, respectively, maintain the integrity of the retinal …

Effects of white light‐emitting diode (LED) exposure on retinal pigment epithelium in vivo

I Jaadane, GE Villalpando Rodriguez… - Journal of cellular …, 2017 - Wiley Online Library
Ageing and alteration of the functions of the retinal pigment epithelium (RPE) are at the
origin of lost of vision seen in age‐related macular degeneration (AMD). The RPE is known …

Retinal pigment epithelium-secretome: A diabetic retinopathy perspective

M Ponnalagu, M Subramani, C Jayadev, R Shetty… - Cytokine, 2017 - Elsevier
Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal
vascular abnormalities and visual impairment. While retinal endothelial pathology is well …

Targeted pharmacotherapy against neurodegeneration and neuroinflammation in early diabetic retinopathy

KD Rolev, X Shu, Y Ying - Neuropharmacology, 2021 - Elsevier
Diabetic retinopathy (DR), the most frequent complication of diabetes, is one of the leading
causes of irreversible blindness in working-age adults and has traditionally been regarded …