Fibroblasts are cells present throughout the human body that are primarily responsible for
the production and maintenance of the extracellular matrix (ECM) within the tissues. They …

The extracellular matrix (ECM) provides structural and biochemical signals that regulate cell
function. A well-controlled balance between cells and surroundings (ie, dynamic reciprocity) …

Kjær, Michael. Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to
Mechanical Loading. Physiol Rev 84: 649–698, 2004; 10.1152/physrev. 00031.2003.—The …

Tissues lose mechanical integrity when our body is injured. To rapidly restore mechanical
stability a multitude of cell types can jump into action by acquiring a reparative phenotype …

Tendons are able to respond to mechanical forces by altering their structure, composition,
and mechanical properties—a process called tissue mechanical adaptation. The fact that …

Structural and functional complexities of the mammalian lung evolved to meet a unique set
of challenges, namely, the provision of efficient delivery of inspired air to all lung units within …

The development of the musculoskeleton and the ability to locomote requires controlled cell
division as well as spatial control over deposition of extracellular matrix. Self-assembly of …

Bronchial asthma is a chronic inflammatory disease in which bronchial wall remodelling
plays a significant role. This phenomenon is related to enhanced proliferation of airway …

Mechanical loads induce changes in the structure, composition, and function of living
tissues. Cells in tissues are responsible for these changes, which cause physiological or …

The effects of fiber alignment and direction of mechanical stimuli on the ECM generation of
human ligament fibroblast (HLF) were assessed. The nanofiber matrix was fabricated using …