Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …

Human pluripotent stem cells (hPSCs) have opened new opportunities for understanding
human development, modelling disease processes and developing new therapeutics …

Multiple sclerosis involves an aberrant autoimmune response and progressive failure of
remyelination in the central nervous system. Prevention of neural degeneration and …

To understand the emergence of human higher cognition, we must understand its biological
substrate—the cerebral cortex, which considers itself the crowning achievement of evolution …

Neonatal engraftment by oligodendrocyte progenitor cells (OPCs) permits the myelination of
the congenitally dysmyelinated brain. To establish a potential autologous source of these …

After years of incremental progress, several recent studies have succeeded in deriving
disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect …

Regeneration of myelin is mediated by oligodendrocyte progenitor cells—an abundant stem
cell population in the central nervous system (CNS) and the principal source of new …

Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology that affects
the CNS. While current therapies are primarily directed against the immune system, the new …

Astrocytes, a subtype of glial cells, come in variety of forms and functions. However,
overarching role of these cell is in the homeostasis of the brain, be that regulation of ions …