Recombination is a prominent feature of meiosis in which it plays an important role in
increasing genetic diversity during inheritance. Additionally, in most organisms …

Meiosis, the mechanism of creating haploid gametes, is a complex cellular process
observed across sexually reproducing organisms. Fundamental to meiosis is the process of …

The DNA-binding protein PRDM9 directs positioning of the double-strand breaks (DSBs)
that initiate meiotic recombination in mice and humans. Prdm9 is the only mammalian …

Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling,
whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive …

Crossing-over ensures accurate chromosome segregation during meiosis, and every pair of
chromosomes obtains at least one crossover, even though the majority of recombination …

Spatial patterning is a ubiquitous feature of biological systems. Meiotic crossovers provide
an interesting example, defined by the classic phenomenon of crossover interference. Here …

The synaptonemal complex (SC) is a proteinaceous complex that apparently mediates
synapsis between homologous chromosomes during meiotic prophase. In Saccharomyces …

Different organisms display widely different numbers of the programmed double-strand
breaks (DSBs) that initiate meiotic recombination (eg, hundreds per meiocyte in mice and …

Repair of the programmed meiotic double-strand breaks (DSBs) that initiate recombination
must be coordinated with homolog pairing to generate crossovers capable of directing …

This review focuses on various aspects of chromosome homology searching and their
relationship to meiotic and vegetative pairing and to the silencing of unpaired copies of …