The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a
critical role in cancer. Although research often concentrates on the tumor's cellular aspect …

Background The cytokine interleukin-2 (IL-2) can stimulate both effector immune cells and
regulatory T (Treg) cells. The ability of selectively engaging either of these effects has …

PURPOSE No combined immunotherapy and antiangiogenic therapy have been
investigated in exclusively programmed death-ligand 1 (PD-L1)–positive advanced cervical …

CD8+ T cells are key antiviral effectors against hepatitis B virus (HBV), yet their number and
function can be compromised in chronic infections. Preclinical HBV models displaying CD8+ …

Molecular insights into the mechanism of beneficial and adverse effects of interleukin-2 (IL-
2) have resulted in the development of improved IL-2 formulations with IL-2 receptor bias …

Simple Summary Breast cancer is one of the most common forms of cancer in women.
Treatment options include immunotherapy where elements of the immune system are used …

The approval of immunotherapies such as checkpoint inhibitors (CPIs), adoptive cell
therapies and cancer vaccines has revolutionized the way cancer treatment is approached …

Simple Summary Cell surface proteases (so-called ectoproteases) are associated with
cancer, and their targeting may confer valuable options for the improvement of cancer …

Despite clinical evidence of antitumor activity, the development of cytokine therapies has
been hampered by a narrow therapeutic window and limited response rates. Two cytokines …

Cervical cancer is one of the most common and lethal cancers among women worldwide.
Treatment options are limited in patients with persistent, recurrent, or metastatic cervical …