Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

Background Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …

Accumulating evidence points to Akkermansia muciniphila as a novel candidate to prevent
or treat obesity-related metabolic disorders. We recently observed, in mice and in humans …

Despite the key roles of perilipin-2 (PLIN2) in governing lipid droplet (LD) metabolism, the
mechanisms that regulate PLIN2 levels remain incompletely understood. Here, we leverage …

Organelle interactions play a significant role in compartmentalizing metabolism and
signaling. Lipid droplets (LDs) interact with numerous organelles, including mitochondria …

Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for
fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and …

Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy
metabolism, membrane synthesis and production of lipid-derived signaling molecules. While …

Lipid droplets are specialized cellular organelles that contain neutral lipid metabolites and
play dynamic roles in energy homeostasis. Perilipin 1 (Plin1), one of the major lipid droplet …

Abstract Aflatoxin B1 (AFB1) is one of the most toxic mycotoxins widely found in food
contaminants, and its target organ is the liver. It poses a major food security and public …

The regenerative capacity of the liver is essential for recovery from surgical resection or
injuries induced by trauma or toxins. During liver regeneration, the concentration of …