Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …

The growing knowledge of ferroptosis has suggested the role and therapeutic potential of
ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer …

The development of life-threatening cancer metastases at distant organs requires
disseminated tumour cells' adaptation to, and co-evolution with, the drastically different …

ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …

Cancer cells display phenotypic equilibrium between the stem-like and differentiated states
during neoplastic homeostasis. The functional and mechanistic implications of this …

Enriched PD-L1 expression in cancer stem-like cells (CSCs) contributes to CSC immune
evasion. However, the mechanisms underlying PD-L1 enrichment in CSCs remain unclear …

The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …

Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ)
are the major downstream effectors of the Hippo pathway, which regulates tissue …

The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …