Advances in nanoparticle-based mRNA delivery for liver cancer and liver-associated infectious diseases

S Chung, CM Lee, M Zhang - Nanoscale horizons, 2023 - pubs.rsc.org
The liver is a vital organ that functions to detoxify the body. Liver cancer and infectious
diseases such as influenza and malaria can fatally compromise liver function. mRNA …

Infections at the nexus of metabolic-associated fatty liver disease

J Boeckmans, M Rombaut, T Demuyser… - Archives of …, 2021 - Springer
Metabolic-associated fatty liver disease (MAFLD) is a chronic liver disease that affects about
a quarter of the world population. MAFLD encompasses different disease stadia ranging …

Neutrophil extracellular traps drive inflammatory pathogenesis in malaria

SL Knackstedt, A Georgiadou, F Apel… - Science …, 2019 - science.org
Neutrophils are essential innate immune cells that extrude chromatin in the form of
neutrophil extracellular traps (NETs) when they die. This form of cell death has potent …

Fenozyme protects the integrity of the blood–brain barrier against experimental cerebral malaria

S Zhao, H Duan, Y Yang, X Yan, K Fan - Nano Letters, 2019 - ACS Publications
Cerebral malaria is a lethal complication of malaria infection characterized by central
nervous system dysfunction and is often not effectively treated by antimalarial combination …

A comprehensive rhythmicity analysis of host proteins and immune factors involved in malaria pathogenesis to decipher the importance of host circadian clock in …

S Rankawat, K Kundal, S Chakraborty… - Frontiers in …, 2023 - frontiersin.org
Background Circadian rhythms broadly impact human health by regulating our daily
physiological and metabolic processes. The circadian clocks substantially regulate our …

Antimalarial efficacy and toxicological assessment of medicinal plant ingredients of Prabchompoothaweep remedy as a candidate for antimalarial drug development

P Chaniad, T Techarang, A Phuwajaroanpong… - … medicine and therapies, 2023 - Springer
Background Drug resistance exists in almost all antimalarial drugs currently in use, leading
to an urgent need to identify new antimalarial drugs. Medicinal plant use is an alternative …

The role of nuclear factor kappa B (NF-κB) in the immune response against parasites

P Bąska, LJ Norbury - Pathogens, 2022 - mdpi.com
The immune system consists of various cells, organs, and processes that interact in a
sophisticated manner to defend against pathogens. Upon initial exposure to an invader …

Severe malaria: Biology, clinical manifestation, pathogenesis and consequences

SN Balaji, R Deshmukh, V Trivedi - Journal of Vector Borne …, 2020 - journals.lww.com
Every year, millions of people are infected with malaria, resulting in significant economic
losses to the developing and developed nations. The malaria parasite pursues a …

Molecular mechanisms of hematological and biochemical alterations in malaria: a review

IU Okagu, RN Aguchem, CA Ezema… - Molecular and …, 2022 - Elsevier
Malaria is a dangerous disease that contributes to millions of hospital visits and hundreds of
thousands of deaths, especially in children residing in sub-Saharan Africa. Although several …

[HTML][HTML] Bilirrubina: metabolismo, pruebas de laboratorio e hiperbilirrubinemia

C Carvajal Carvajal - Medicina Legal de Costa Rica, 2019 - scielo.sa.cr
La bilirrubina es el producto final de la degradación del grupo hem. La bilirrubina no
conjugada (BNC) se forma en las células retículoendoteliales, transportada al hígado …