Induction of reproductive injury by bisphenol A and the protective effects of cyanidin-3-O-glucoside and protocatechuic acid in rats

R Liu, B Liu, L Tian, X Wu, X Li, D Cai, X Jiang… - Science of the Total …, 2023 - Elsevier
Bisphenol A (BPA) has attracted growing attention as a well-known environmental pollutant
due to its high risk of male reproductive toxicity. In this study, transcriptomics profiling …

Effects of dehydroepiandrosterone on the ovarian reserve and pregnancy outcomes in perimenopausal rats (DHEA and fertility in perimenopausal rats)

YI Mahmoud, AA Mahmoud, FS Abo-Zeid, NH Fares - Life sciences, 2018 - Elsevier
Background Dehydroepiandrosterone (DHEA) is a weak androgen and a crucial precursor
of sex steroids. Exogenous supplementation of DHEA is now being commonly used to …

Activation of aryl hydrocarbon receptor protein promotes testosterone synthesis to alleviate abnormal spermatogenesis caused by cholestasis

L Wang, Q Han, Y Liu, X Ma, H Han, L Yan… - International Journal of …, 2024 - Elsevier
In this study, we have investigated potential roles of cholestasis played in spermatogenesis
in the cholestatic animal model generated by giving the mice DDC diet. The data showed …

Chronic cholestasis is associated with hypogonadism and premature ovarian failure in adult rats (cholestasis causes ovarian hypogonadism)

YI Mahmoud - Ultrastructural Pathology, 2018 - Taylor & Francis
Hypogonadism is a well-known complication in males with chronic liver diseases. However,
the consequences of chronic hepatopathies on female reproductive capacities have …

Aspartic acid ameliorates cholestasis in bile duct-ligated rats

MF Elnagar, YI Mahmoud… - Egyptian Journal of …, 2023 - journals.ekb.eg
Background: Amino acids are promising agents in a variety of therapeutic fields including
proliferation management. D-aspartic acid (DAA) is a non-essential amino acid, which …

Effects of liver‐regulating herb compounds on testicular morphological and ultrastructural changes in varicocele rats through SCF/C‐KIT pathway

X Lu, J Liu, H Yin, C Ding, Y Wang, F Zhang, G Jin… - Andrologia, 2020 - Wiley Online Library
Liver‐regulating herb compound (LRHC) has good effects on improving sperm quality and
male fertility of varicocele (VC) patients. But the mechanism of LRHC on VC is still not clear …

Investigation of cholestasis‐related changes in characteristics of spermatogonial stem cells in testis tissue of male Wistar rats

AH Hasani Fard, H Mohseni Kouchesfehani… - Andrologia, 2020 - Wiley Online Library
Paternal metabolic status is an important factor in the health status of offspring. Cholestasis,
as a metabolic disorder, significantly disrupts spermatogenesis. Spermatogonial stem cells …

Perspectives of ursodeoxycholic acid application in clinical practice

AM Morozov, AV Kadykov, NA Sergeev… - Vrach, 2024 - journals.eco-vector.com
The possibilities of ursodeoxycholic acid (UDCA) application in clinical practice are
evaluated. Statistical analysis of data from modern Russian and foreign literature sources …

Опыт анализа биологической активности урсодезоксихолевой кислоты в контексте in silico прогноза профиля экспрессии генов

ЯБ Нескородов, СГ Марданлы, РН Чупров-Неточин - Генетика, 2020 - elibrary.ru
В настоящей статье была впервые предпринята попытка анализа биологической
активности урсодезоксихолевой кислоты в контексте предсказанного in silico …

Нарушения в мозге при холестазе и пути коррекции

СВ Емельянчик, СМ Зиматкин - 2016 - elibrary.ru
Монография посвящена изменениям нейронов разных отделов головного мозга
(фронтальная, теменная кора, кора мозжечка и ядро Е2 заднего гипоталамуса) при …