FGFR inhibitors in oncology: insight on the management of toxicities in clinical practice
Simple Summary FGFR inhibitors evolved as therapeutic options in cholangiocarcinoma
and urothelial malignancies. Given the implications of FGFR pathway in various …
and urothelial malignancies. Given the implications of FGFR pathway in various …
Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment
R Ruan, L Li, X Li, C Huang, Z Zhang, H Zhong… - Molecular Cancer, 2023 - Springer
Abstract Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) play a
crucial role in cell fate and angiogenesis, with dysregulation of the signaling axis driving …
crucial role in cell fate and angiogenesis, with dysregulation of the signaling axis driving …
Fibroblast growth factor receptor 3 alterations and response to immune checkpoint inhibition in metastatic urothelial cancer: a real world experience
Background FGFR3-altered urothelial cancer (UC) correlates with a non-T cell-inflamed
phenotype and has therefore been postulated to be less responsive to immune checkpoint …
phenotype and has therefore been postulated to be less responsive to immune checkpoint …
FGFR inhibition augments anti–PD-1 efficacy in murine FGFR3-mutant bladder cancer by abrogating immunosuppression
The combination of targeted therapy with immune checkpoint inhibition (ICI) is an area of
intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) …
intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) …
Futibatinib, an Irreversible FGFR1-4 Inhibitor for the Treatment of FGFR-Aberrant Tumors
Fibroblast growth factor receptors (FGFR) are emerging as an important therapeutic target
for patients with advanced, refractory cancers. Most selective FGFR inhibitors under …
for patients with advanced, refractory cancers. Most selective FGFR inhibitors under …
Targeting the fibroblast growth factor receptor (FGFR) family in lung cancer
Lung cancer is the most common cause of cancer-related deaths globally. Genetic
alterations, such as amplifications, mutations and translocations in the fibroblast growth …
alterations, such as amplifications, mutations and translocations in the fibroblast growth …
Targetable pathways in advanced bladder cancer: FGFR signaling
Simple Summary Around 20% of advanced bladder cancer patients carry unfavorable
genetic alterations in the fibroblast growth factor receptor 3 (FGFR3) gene. This review …
genetic alterations in the fibroblast growth factor receptor 3 (FGFR3) gene. This review …
Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma
M Kono, H Komatsuda, H Yamaki, T Kumai… - …, 2022 - Taylor & Francis
Fibroblast growth factor receptor 1 (FGFR1) is overexpressed in multiple types of solid
tumors, including head and neck squamous cell carcinoma (HNSCC). Being associated with …
tumors, including head and neck squamous cell carcinoma (HNSCC). Being associated with …
FGFR pathway inhibition in gastric cancer: the golden era of an old target?
CG Lengyel, S Hussain, A Seeber… - Life, 2022 - mdpi.com
Gastric cancer (GC) is the third leading cause of cancer-associated death worldwide. The
majority of patients are diagnosed at an advanced/metastatic stage of disease due to a lack …
majority of patients are diagnosed at an advanced/metastatic stage of disease due to a lack …
Immunotherapy in advanced biliary tract cancers
Simple Summary A new era has emerged in oncology in the last ten years with the
development of immune therapies. However, single-agent immune therapy such as immune …
development of immune therapies. However, single-agent immune therapy such as immune …