Rho GTPases: Regulation and roles in cancer cell biology
RB Haga, AJ Ridley - Small GTPases, 2016 - Taylor & Francis
Rho GTPases are well known for their roles in regulating cell migration, and also contribute
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …
STAT3 target genes relevant to human cancers
RL Carpenter, HW Lo - Cancers, 2014 - mdpi.com
Since its discovery, the STAT3 transcription factor has been extensively studied for its
function as a transcriptional regulator and its role as a mediator of development, normal …
function as a transcriptional regulator and its role as a mediator of development, normal …
[HTML][HTML] A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction
The pro-oncogenic transcription factor STAT3 is constitutively activated in a wide variety of
tumours that often become addicted to its activity, but no unifying view of a core function …
tumours that often become addicted to its activity, but no unifying view of a core function …
Targeting STAT3 in cancer and autoimmune diseases
T Gharibi, Z Babaloo, A Hosseini… - European journal of …, 2020 - Elsevier
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is
activated downstream of a broad range of receptors particularly interleukin-6 (IL-6) family …
activated downstream of a broad range of receptors particularly interleukin-6 (IL-6) family …
STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses
L Avalle, A Camporeale, G Morciano… - Cell Death & …, 2019 - nature.com
STAT3 is an oncogenic transcription factor exerting its functions both as a canonical
transcriptional activator and as a non-canonical regulator of energy metabolism and …
transcriptional activator and as a non-canonical regulator of energy metabolism and …
Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten
The transcription factor signal transducer and activator of transcription 3 (STAT3) is
constitutively activated in tumors of different origin, but the molecular bases for STAT3 …
constitutively activated in tumors of different origin, but the molecular bases for STAT3 …
PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion
AE Dart, GM Box, W Court, ME Gale, JP Brown… - Journal of Cell …, 2015 - rupress.org
P21-activated kinase 4 (PAK4) is a Cdc42 effector protein thought to regulate cell adhesion
disassembly in a kinase-dependent manner. We found that PAK4 expression is significantly …
disassembly in a kinase-dependent manner. We found that PAK4 expression is significantly …
Stroma-derived miR-214 coordinates tumor dissemination
F Orso, F Virga, D Dettori, A Dalmasso… - Journal of Experimental …, 2023 - Springer
Background Tumor progression is based on a close interaction between cancer cells and
Tumor MicroEnvironment (TME). Here, we focus on the role that Cancer Associated …
Tumor MicroEnvironment (TME). Here, we focus on the role that Cancer Associated …
GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling
Dysregulated JAK/STAT signaling has been implicated in breast cancer metastasis, which is
associated with high relapse risks. However, mechanisms underlying JAK/STAT signaling …
associated with high relapse risks. However, mechanisms underlying JAK/STAT signaling …
OVOL2 impairs RHO GTPase signaling to restrain mitosis and aggressiveness of Anaplastic Thyroid Cancer
M Gugnoni, G Manzotti, E Vitale, E Sauta… - Journal of Experimental …, 2022 - Springer
Abstract Background Anaplastic Thyroid Cancer (ATC) is an undifferentiated and aggressive
tumor that often originates from well-Differentiated Thyroid Carcinoma (DTC) through a trans …
tumor that often originates from well-Differentiated Thyroid Carcinoma (DTC) through a trans …